Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
M.D. Anderson Cancer Center
Modality
vaccine
Development Phase
Phase 2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03439085CT.gov DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine INO-3112 and Durvalumab in Treating Patients With Recurrent or Metastatic Human Papillomavirus Associated Cancers | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Anal Canal Carcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Plasmid Encoded Il-12 (this asset) | M.D. Anderson Cancer Center | P2 | CCC · 53 |
| Carboplatin | ECOG-ACRIN Cancer Research Group | P2 | B |
| Fluorouracilum | ECOG-ACRIN Cancer Research Group | P2 | B |
| Toripalimab | Sun Yat-sen University | P2 | B |
| Cis-Diamminedichloroplatinum Ii | M.D. Anderson Cancer Center | P2 | B |
| Durvalumab | M.D. Anderson Cancer Center | P2 | CCC |
| Capecitabine | ECOG-ACRIN Cancer Research Group | P2 | CCC |
| Ipilimumab | National Cancer Institute (NCI) | P2 | CCC |
| Nivolumab | National Cancer Institute (NCI) | P2 | CCC |
+6 more in the Anal Canal Carcinoma cohort
Other indications for Plasmid Encoded Il-12
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Human Papilloma Virus Infection | — | P2 | CCC · 53 |
| Metastatic Malignant Neoplasm | — | P2 | CCC · 53 |
| Cervical Carcinoma | — | P2 | CCC · 53 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Plasmid Encoded Il-12 in Anal Canal Carcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/plasmid-encoded-il-12-anal-canal-carcinoma
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