Pralatrexate
Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
Explore 59 assets in Primary Cutaneous T-Cell Non-Hodgkin Lymphoma →Floatz Rating
CCC50/100
Confidence
Indicative
Sponsor
University of Virginia
Modality
Small molecule
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
37High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03240211CT.gov Study of Pembrolizumab Combined With Decitabine and Pralatrexate in PTCL and CTCL | — | Active Not Recruiting | — | — | — |
NCT01134341CT.gov Pralatrexate and Bexarotene in Patients With Relapsed or Refractory Cutaneous T-cell Lymphoma | — | Completed | — | — | — |
NCT00554827CT.gov Study of Pralatrexate in Patients With Relapsed or Refractory Cutaneous T-cell Lymphoma | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Pralatrexate (this asset) | University of Virginia | P1 | CCC · 50 |
| (+)-Vincristine | Shanghai Jiao Tong University School of Medicine | P4 | BBB |
| Cyclophosphamide | Shanghai Jiao Tong University School of Medicine | P4 | BBB |
| Bexarotene | Case Comprehensive Cancer Center | P4 | BBB |
| Dexasone | National Cancer Institute (NCI) | P2 | BBB |
| Fludarabine | National Cancer Institute (NCI) | P2 | BBB |
| Adriamycin | Falo, Louis, MD | P4 | BBB |
| Nivestim | City of Hope Medical Center | P4 | BBB |
| Mogamulizumab | University of Michigan Rogel Cancer Center | P4 | BB |
+42 more in the Primary Cutaneous T-Cell Non-Hodgkin Lymphoma cohort
Other indications for Pralatrexate
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Peripheral T-Cell Lymphoma, Not Otherwise Specified | — | P4 | BBB · 74 |
| Angioimmunoblastic T-Cell Lymphoma | — | P3 | BB · 66 |
| Nodal T-Follicular Helper Cell Lymphoma, Follicular Type | — | P3 | BB · 64 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Pralatrexate in Primary Cutaneous T-Cell Non-Hodgkin Lymphoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/pralatrexate-primary-cutaneous-t-cell-non-hodgkin-lymphoma
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