Floatz Rating
CC43/100
Confidence
Indicative
Sponsor
Otsuka Pharmaceutical Development & Commercialization, Inc.
Modality
Small molecule
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT02655354CT.gov A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Post-Traumatic Stress Disorder
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Prazosin (this asset) | Otsuka Pharmaceutical Development & Commercialization, Inc. | P1 | CC · 43 |
| (±)-2-(O-Chlorophenyl)-2-(Methylamino)Cyclohexanone | Queen's University | P4 | BBB |
| Sertraline | Yang I. Pachankis, PhD | P4 | BB |
| Paroxetine | University of Washington | P4 | BB |
| Escitalopram | New York State Psychiatric Institute | P4 | BB |
| Methylphenidate | VA Office of Research and Development | P4 | BB |
| Duloxetine | Yang I. Pachankis, PhD | P4 | B |
| Midomafetamine | MAPS Europe B.V. | P2 | B |
| Teonanacatl | Anthony P King | P2 | B |
+31 more in the Post-Traumatic Stress Disorder cohort
Other indications for Prazosin
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Portal Hypertension | — | P4 | BB · 65 |
| Dementia | — | P4 | B · 62 |
| Cirrhosis Of Liver | — | P4 | B · 62 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Prazosin in Post-Traumatic Stress Disorder. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/prazosin-post-traumatic-stress-disorder
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