Progerinin
Hutchinson-Gilford Progeria Syndrome
Explore 2 assets in Hutchinson-Gilford Progeria Syndrome →Floatz Rating
B60/100
Confidence
Indicative
Sponsor
PRG Science & Technology Co., Ltd.
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
45Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06775041CT.gov Study to Determine Optimal Dose and Evaluate Safety, Tolerability, and Pharmacokinetics of Progerinin in Patients With Hutchinson-Gilford Progeria Syndrome (HGPS) | — | Active Not Recruiting | — | — | — |
NCT04512963CT.gov Phase I Study of Progerinin in Healthy Volunteers | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Indicative
Detailed axis rationale is planned and will be published soon.
Same indication · Hutchinson-Gilford Progeria Syndrome
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Progerinin (this asset) | PRG Science & Technology Co., Ltd. | P2 | B · 60 |
| Pravastatin | Boston Children's Hospital | P2 | B |
| Zoledronate | Boston Children's Hospital | P2 | B |
| Lonafarnib | PRG Science & Technology Co., Ltd. | P2 | B |
Other indications for Progerinin
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Werner Syndrome | — | P2 | B · 60 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Progerinin in Hutchinson-Gilford Progeria Syndrome. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/progerinin-hutchinson-gilford-progeria-syndrome
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