Floatz Rating
CCC49/100
Confidence
Indicative
Sponsor
National Heart Centre Singapore
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06645691CT.gov Hyperpolarized MR Imaging with Carbon-13 Pyruvate in the Human Body | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Heart Failure
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Pyruvate (this asset) | National Heart Centre Singapore | P2 | CCC · 49 |
| Empagliflozin | Jacob Moller | P4 | BB |
| Finerenone | Hospital de Messejana Dr. Carlos Alberto Studart Gomes | P4 | BB |
| Semaglutide | University Medical Centre Ljubljana | P2/3 | BB |
| Carvedilol | Abramson Cancer Center at Penn Medicine | P3 | BB |
| Rivaroxaban | Janssen Research & Development, LLC | P3 | B |
| Acalabrutinib | AstraZeneca | P4 | B |
| Sacubitril Valsartan | Silesian Centre for Heart Diseases | P4 | B |
| Spironolactone | Hospital de Messejana Dr. Carlos Alberto Studart Gomes | P4 | B |
+32 more in the Heart Failure cohort
Other indications for Pyruvate
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Prostate Cancer | — | P2 | B · 56 |
| Prostate Carcinoma | — | P2 | B · 56 |
| Relapsing-Remitting Multiple Sclerosis | — | P2 | CCC · 52 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Pyruvate in Heart Failure. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 13, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/pyruvate-heart-failure
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