Realgar-Indigo Naturalis Formulation
Acute Promyelocytic Leukemia
Explore 20 assets in Acute Promyelocytic Leukemia →Floatz Rating
BB66/100
Confidence
Indicative
Sponsor
Instituto do Cancer do Estado de São Paulo
Modality
UNKNOWN
Development Phase
Phase 3
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
52Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06982274CT.gov Oral Arsenic With ATRA for Newly Diagnosed Patients With Acute Promyelocytic Leukemia | — | Recruiting | — | — | — |
NCT04175587CT.gov Randomized,International Multi-center Clinical Trial of RIF Plus RA for Non-high-risk APL | — | Unknown | — | — | — |
NCT02899169CT.gov Treatment of Non-high-risk Acute Promyelocytic Leukemia (APL) With Realgar-Indigo Naturalis Formula (RIF) | — | Unknown | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Indicative
Detailed axis rationale is planned and will be published soon.
Same indication · Acute Promyelocytic Leukemia
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Realgar-Indigo Naturalis Formulation (this asset) | Instituto do Cancer do Estado de São Paulo | P3 | BB · 66 |
| Cytarabine | Associazione Italiana Ematologia Oncologia Pediatrica | P4 | A |
| Tretinoin | The Affiliated People's Hospital of Ningbo University | P4 | A |
| Idarubicin | Technische Universität Dresden | P4 | A |
| Arsenic Trioxide | Quetzal Therapeutics | P4 | BBB |
| Mitoxantrone | Technische Universität Dresden | P4 | BBB |
| Daunomycin | Peking University People's Hospital | P4 | BBB |
| Methotrexate | Technische Universität Dresden | P3 | BBB |
| Etoposide | Peking University People's Hospital | P2 | BBB |
+42 more in the Acute Promyelocytic Leukemia cohort
Other indications for Realgar-Indigo Naturalis Formulation
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Ovarian Cancer | — | P4 | BB · 65 |
| Childhood Acute Lymphoblastic Leukemia | — | P4 | BB · 65 |
| Acute Myeloid Leukemia | — | P1 | C · 36 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Realgar-Indigo Naturalis Formulation in Acute Promyelocytic Leukemia. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/realgar-indigo-naturalis-formulation-acute-promyelocytic-leukemia
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