Floatz Rating
CC47/100
Confidence
Indicative
Sponsor
Bristol-Myers Squibb
Modality
Small molecule
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
32Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06352528CT.gov A Study to Assess the Drug Levels of Repotrectinib in Healthy Participants and Participants With Moderate and Severe Hepatic Impairment | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Liver Disorder
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Repotrectinib (this asset) | Bristol-Myers Squibb | P1 | CC · 47 |
| Pioglitazone | Yonsei University | P4 | BBB |
| Metformin | Taipei City Hospital | P4 | BBB |
| Empagliflozin | Military University Hospital, Prague | P4 | BB |
| 10-(1-methylpiperidin-4-ylidene)-5,10-dihydro-4H-benzo[5,6]cyclohepta[1,2-b]thiophen-4-one | Tanta University | P4 | BB |
| Glibenclamide | Takeda | P4 | BB |
| Hep-V Vax | University of Oxford | P4 | BB |
| Alpha Tocopherol | Tanta University | P4 | BB |
| Shen Pu Yang Gan Wan | Taipei Medical University WanFang Hospital | P4 | BB |
+42 more in the Liver Disorder cohort
Other indications for Repotrectinib
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Non-Small Cell Lung Carcinoma | — | P3 | CCC · 54 |
| Hormone Receptor-Positive Breast Cancer | — | P2 | CCC · 52 |
| Invasive Lobular Breast Carcinoma | — | P2 | CCC · 52 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Repotrectinib in Liver Disorder. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/repotrectinib-liver-disorder
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