Floatz Rating
B61/100
Confidence
Indicative
Sponsor
4SC AG
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
49High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04955340CT.gov A Phase 1, Open-label Study of the Absorption, Metabolism, Excretion of [14C]-Resminostat | — | Completed | — | — | — |
NCT02953301CT.gov Resminostat for Maintenance Treatment of Patients With Advanced Stage Mycosis Fungoides (MF) or Sézary Syndrome (SS) | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Sezary Syndrome
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Resminostat (this asset) | 4SC AG | P2 | B · 61 |
| Cyclophosphamide | Shanghai Jiao Tong University School of Medicine | P4 | BB |
| Prednisone | Shanghai Jiao Tong University School of Medicine | P4 | BB |
| (+)-Vincristine | Shanghai Jiao Tong University School of Medicine | P4 | BB |
| Cyclosporin A | Ohio State University Comprehensive Cancer Center | P2 | BB |
| Phosphonic Acid, P-[3-[[(2R,3R)-2-[(1R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethoxy]-3-(4-Fluorophenyl)-4-Morpholinyl]Methyl]-2,5-Dihydro-5-Oxo-1H-1,2,4-Triazol-1-Yl]- | Vanderbilt University Medical Center | P4 | B |
| Mogamulizumab | Kyowa Kirin Co., Ltd. | P2 | B |
| Denileukin Diftitox | Eisai Inc. | P4 | B |
| Brentuximab Vedotin | City of Hope Medical Center | P2 | B |
+32 more in the Sezary Syndrome cohort
Other indications for Resminostat
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Mycosis Fungoides | — | P2 | B · 61 |
| Primary Cutaneous T-Cell Non-Hodgkin Lymphoma | — | P2 | B · 61 |
| Hepatocellular Carcinoma | — | P2 | B · 58 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
- CyclophosphamideShanghai Jiao Tong University School of MedicineBB
- PrednisoneShanghai Jiao Tong University School of MedicineBB
- (+)-VincristineShanghai Jiao Tong University School of MedicineBB
- Cyclosporin AOhio State University Comprehensive Cancer CenterBB
- Phosphonic Acid, P-[3-[[(2R,3R)-2-[(1R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethoxy]-3-(4-Fluorophenyl)-4-Morpholinyl]Methyl]-2,5-Dihydro-5-Oxo-1H-1,2,4-Triazol-1-Yl]-Vanderbilt University Medical CenterB
Citation
Floatz Terminal. Resminostat in Sezary Syndrome. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/resminostat-sezary-syndrome
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