Floatz Rating
BB68/100
Confidence
Indicative
Sponsor
Pakistan Institute of Medical Sciences
Modality
Small molecule
Development Phase
Phase 4 / Approved
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
60High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04580134CT.gov CLOZAPINE Response in Biotype-1 | — | Recruiting | — | — | — |
NCT01495156CT.gov Study of the Efficacy of Adjunctive Lithium Treatment for the Treatment of Psychotic Mania | — | Withdrawn | — | — | — |
NCT00857818CT.gov Trial Comparing the Effects of Aripiprazole With Those of Standard of Care on Non-HDL Cholesterol in Patients With Schizophrenia or Bipolar I Disorder Who Have Metabolic Syndrome | — | Terminated | — | — | — |
NCT01977300CT.gov Atypical Antipsychotics for Continuation and Maintenance Treatment After an Acute Manic Episode | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Bipolar I Disorder
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Risperidone (this asset) | Pakistan Institute of Medical Sciences | Approved | BB · 68 |
| Lurasidone | Massachusetts General Hospital | P4 | BBB |
| Lithium, Elemental | Alzamend Neuro, Inc. | P4 | BBB |
| Escitalopram | Massachusetts General Hospital | P4 | BBB |
| Olanzapine | Alkermes, Inc. | P4 | BBB |
| Asenapine | Organon and Co | P3 | BBB |
| Lamotrigine | Bristol-Myers Squibb | P4 | BBB |
| Cariprazine | Pakistan Institute of Medical Sciences | P4 | BBB |
| Iloperidone | Vanda Pharmaceuticals | P4 | BBB |
+42 more in the Bipolar I Disorder cohort
Other indications for Risperidone
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Major Depressive Disorder | — | P4 | BBB · 78 |
| Psychotic Disorder | — | P4 | BBB · 77 |
| Schizoaffective Disorder | — | P4 | BBB · 77 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Risperidone in Bipolar I Disorder. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/risperidone-bipolar-i-disorder
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