S-Gboxin
Diffuse Midline Glioma, H3 K27M-Mutant
Explore 10 assets in Diffuse Midline Glioma, H3 K27M-Mutant →Floatz Rating
CC41/100
Confidence
Indicative
Sponsor
Petrov, Andrey
Modality
UNKNOWN
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06806228CT.gov Phase I Pilot Study to Evaluate the Anti-glioblastoma Effect of S-Gboxin in Standard Treatment of Glioblastoma/Diffuse Midline Glioma and Response to Treatment (Regardless of Mutation Status) | — | Suspended | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Diffuse Midline Glioma, H3 K27M-Mutant
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| S-Gboxin (this asset) | Petrov, Andrey | P1 | CC · 41 |
| Ribociclib | Nationwide Children's Hospital | P2 | B |
| Olutasidenib | Rigel Pharmaceuticals | P2 | CCC |
| Everolimus | Nationwide Children's Hospital | P2 | CCC |
| Trametinib | St. Jude Children's Research Hospital | P1 | CC |
| Nivestim | St. Jude Children's Research Hospital | P1 | CC |
| Pegargiminase | Sabine Mueller, MD, PhD | P1/2 | CC |
| Sonidegib | St. Jude Children's Research Hospital | P1 | CC |
| Amxt1501 | Aminex Therapeutics, Inc. | P1/2 | CC |
+6 more in the Diffuse Midline Glioma, H3 K27M-Mutant cohort
Other indications for S-Gboxin
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Giant Cell Glioblastoma | — | P1 | CC · 43 |
| Glioblastoma | — | P1 | CC · 41 |
| Gliosarcoma | — | P1 | CC · 41 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. S-Gboxin in Diffuse Midline Glioma, H3 K27M-Mutant. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/s-gboxin-diffuse-midline-glioma-h3-k27m-mutant
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