Floatz Rating
BB67/100
Confidence
Indicative
Sponsor
Jing Liu
Modality
Small molecule
Development Phase
Phase 4 / Approved
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
57Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT07241338CT.gov Sacubitril/Allisartan for Hypertensive Patients With Overweight or Obesity | — | Not Yet Recruiting | — | — | — |
NCT04971720CT.gov PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm Axis | — | Recruiting | — | — | — |
NCT05498675CT.gov Effect of Sacubitril/Valsartan on Cardiac Function in Hypertensive Patients Stratified by BMI: A Real World Study | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Hypertensive Disorder
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Sacubitril (this asset) | Jing Liu | Approved | BB · 67 |
| Valsartan | University of Alabama at Birmingham | P4 | BBB |
| Hydrochlorothiazide | University of Kansas Medical Center | P4 | BBB |
| Losartan | Rong Zhang | P4 | BBB |
| Amlodipine | Jing Liu | P4 | BBB |
| Olmesartan Medoxomil | Virginia Polytechnic Institute and State University | P4 | BBB |
| Corpril | University of Michigan | P4 | BBB |
| Trandolapril | University of Florida | P4 | BBB |
| Verapamil Slow Release | Abbott | P4 | BBB |
+42 more in the Hypertensive Disorder cohort
Other indications for Sacubitril
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Heart Failure | — | P2 | B · 57 |
| Breast Cancer | — | P2 | B · 57 |
| Obesity Disorder | — | P2/3 | CCC · 48 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Sacubitril in Hypertensive Disorder. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/sacubitril-hypertensive-disorder
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