Semaglutide
Obesity Disorder
Floatz Rating
BBB72/100
Confidence
Indicative
Sponsor
Ali Aminian
Modality
protein_peptide
Development Phase
Phase 4 / Approved
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
77High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT07027969CT.gov Metabolic Surgery for Atrial Fibrillation Elimination | — | Not Yet Recruiting | — | — | — |
NCT07622810CT.gov BALANCE-OBS: Bofanglutide (GZR18) Versus Semaglutide in Latin American Adults With Overweight or Obesity | — | Not Yet Recruiting | — | — | — |
NCT07411378CT.gov Testing the Efficacy, Safety, and PK of 20E in Patients With Obesity Who Are Starting Treatment With the GLP-1 Agonist Semaglutide for Weight Loss. | — | Not Yet Recruiting | — | — | — |
NCT07639021CT.gov A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity | — | Not Yet Recruiting | — | — | — |
NCT07570810CT.gov Efficacy, Safety, and Tolerability of CS0159 Combined With Semaglutide in MAFLD Patients With Obesity and T2DM | — | Not Yet Recruiting | — | — | — |
NCT06934655CT.gov Early Re-Initiation of Semaglutide Post Sleeve Gastrectomy in Youth | — | Not Yet Recruiting | — | — | — |
NCT07564414CT.gov A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight | — | Recruiting | — | — | — |
NCT07400107CT.gov AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight | — | Not Yet Recruiting | — | — | — |
NCT07597018CT.gov A Research Study to Compare Blood Levels of Cagrilintide After Multiple Doses of Different Versions of Cagrilintide in Adults With Overweight or Obesity | — | Not Yet Recruiting | — | — | — |
NCT07021937CT.gov Brain Plasticity and GLP-1 Receptor Agonist Treatment for Obesity | — | Not Yet Recruiting | — | — | — |
Show 111 more trialsShow fewer
NCT07633639CT.gov GLP-1 Therapy After Bariatric Surgery in Chinese Patients With Obesity | — | Recruiting | — | — | — |
NCT07588984CT.gov GLP-1 Medication & Behavioral Health Programs on Weight & Metabolic Outcomes: FLOURISH and THRIVE Prospective Cohort Study | — | Not Yet Recruiting | — | — | — |
NCT07653412CT.gov Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists. | — | Recruiting | — | — | — |
NCT07527195CT.gov Understanding the Effect of CagriSema, Cagrilintide, and Semaglutide on Muscle Health (Role of Amylin Signature in Muscle Health) | — | Recruiting | — | — | — |
NCT07466017CT.gov A Study of CS060380 Tablets in Patients With MASH and Obesity | — | Recruiting | — | — | — |
NCT07430059CT.gov Safety, Tolerability and Pharmacokinetics of a Subcutaneous Semaglutide Implant | — | Not Yet Recruiting | — | — | — |
NCT07446998CT.gov Proof-of-Concept Study Evaluating Total Body Weight, Physical Function & Safety of Enobosarm in Patients Treated With GLP-1 Receptor Agonist, for Weight Loss | — | Recruiting | — | — | — |
NCT07505303CT.gov MIST (Metabolic Intervention With Semaglutide and THR-β Therapy) Trial | — | Not Yet Recruiting | — | — | — |
NCT07465965CT.gov A Clinical Study of Semaglutide Nasal Spray in Overweight or Obese Adults | — | Recruiting | — | — | — |
NCT06836284CT.gov The Evira Study: Additional Support During Obesity Treatment | — | Recruiting | — | — | — |
NCT07619508CT.gov Tirzepatide vs Semaglutide in Individuals at Cardiovascular Risk But Without Diabetes. | — | Active Not Recruiting | — | — | — |
NCT07417618CT.gov INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without ASCVD (INTERCEPT-ASCVD) | — | Active Not Recruiting | — | — | — |
NCT07213466CT.gov Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder | — | Recruiting | — | — | — |
NCT07253285CT.gov A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight | — | Recruiting | — | — | — |
NCT07172867CT.gov A Ph2 Study to Evaluate the Safety, Efficacy and Tolerability of HT-6184 and Semaglutide in Obese Participants With T2DM | — | Withdrawn | — | — | — |
NCT07284979CT.gov Efficacy and Safety of KAI-9531 Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes | — | Recruiting | — | — | — |
NCT07319975CT.gov Effect of Semaglutide and Tirzepatide Combined With Exercise in Obesity | — | Not Yet Recruiting | — | — | — |
NCT07285902CT.gov A Study Comparing the Efficacy and Safety of HRS9531 Injection With Semaglutide Injection in Subjects With Obesity | — | Active Not Recruiting | — | — | — |
NCT07275697CT.gov Waiting on Atrial Fibrillation Intervention Therapy (WAIT) Study | — | Not Yet Recruiting | — | — | — |
NCT07225816CT.gov Examination of How the Duration of Fasting and Temporary Stopping of GLP-1 Medications Affect the Amount of Food Left in the Stomach in People Using Liraglutide (Injected), Semaglutide (Taken by Mouth) or Semaglutide (Injected) | — | Recruiting | — | — | — |
NCT06801015CT.gov Effects of Long-Acting GLP-1 (Glucagon-like Peptide-1) or Dual Incretin (GLP-1 and GIP [Glucose-dependent Insulinotropic Peptide]) Modulation on Gastric Motor Functions | — | Active Not Recruiting | — | — | — |
NCT06909006CT.gov Semaglutide Treatment in Type 1 Diabetes | — | Not Yet Recruiting | — | — | — |
NCT07184086CT.gov A Study to See How Metabolism is Influenced by Weight Loss Due to Intervention With Cagrilintide and Semaglutide Compared to Diet | — | Recruiting | — | — | — |
NCT07150975CT.gov Phase III Clinical Study Comparing the Efficacy and Safety of GZR18 Injection and Semaglutide (Wegovy®) in Adult Obese or Overweight Subjects | — | Recruiting | — | — | — |
NCT07513168CT.gov Low-Dose Semaglutide for Weight Loss in Obese Non-Diabetic Pakistani Adults | — | Recruiting | — | — | — |
NCT07073417CT.gov A Study to Compare XW003 Injection and Semaglutide Injection in Chinese Adults With Obesity (SLIMMER-UP-SWITCH) | — | Active Not Recruiting | — | — | — |
NCT07101939CT.gov A Study of the Effect of (S)-Pindolol Benzoate (ACM-001.1) on Lean Body Mass (LBM) in Obese Patents During (PROACT 1), and Post-semaglutide Therapy (PROACT 2) | — | Recruiting | — | — | — |
NCT06852391CT.gov JOULE - Metabolic Adaptation to Weight Loss in Response to a Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity | — | Recruiting | — | — | — |
NCT07010432CT.gov The Role of the Amylin Analogue Cagrilintide in Bone Metabolism | — | Recruiting | — | — | — |
NCT06967389CT.gov Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity | — | Recruiting | — | — | — |
NCT07011667CT.gov A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-term | — | Active Not Recruiting | — | — | — |
NCT07293325CT.gov Semaglutide and Tirzepatide for Genetic Aging Delay in Adults With Obesity | — | Recruiting | — | — | — |
NCT07057310CT.gov Aging Well: Targeting Obesity With GLP-1 Agonists to Enhance Physical and Vascular Health in Postmenopausal Women | — | Enrolling By Invitation | — | — | — |
NCT06972992CT.gov A Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASC47 in Combination With Semaglutide | — | Completed | — | — | — |
NCT06619015CT.gov Tailoring Obesity Treatment Trial | — | Withdrawn | — | — | — |
NCT06745284CT.gov A Study to Test Whether Survodutide Improves How the Body Uses Energy and Breaks Down Fat in People With Obesity | — | Active Not Recruiting | — | — | — |
NCT06738979CT.gov A Clinical Study Comparing Semaglutide Injection and Wegovy® for Weight Management in Obese Subjects | — | Not Yet Recruiting | — | — | — |
NCT06830343CT.gov The Safety, Tolerability, and Pharmacokinetics of of SYH9017 in Chinese Participants With Overweight and Obesity | — | Recruiting | — | — | — |
NCT06825793CT.gov Semaglutide's Weight Loss Effects in Obesity | — | Not Yet Recruiting | — | — | — |
NCT06780449CT.gov A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Obesity | — | Active Not Recruiting | — | — | — |
NCT06896981CT.gov Semaglutide in Women With Polycystic Ovary Syndrome and Obesity | — | Recruiting | — | — | — |
NCT06803888CT.gov Bariatric Surgery vs. Semaglutide vs. Tirzepatide | — | Active Not Recruiting | — | — | — |
NCT06771115CT.gov Phase 2a Placebo-Controlled Study of VTX3232 Alone or in Combination With Semaglutide in Obesity | — | Completed | — | — | — |
NCT06754163CT.gov Evaluating the Effect of the STEP@STAH Semaglutide Protocol on the Physical Health Measures of Atypical Antipsychotic-Treated Patients | — | Active Not Recruiting | — | — | — |
NCT05670379CT.gov Assessment of Safety, Tolerability and Drug Levels of Exenatide Implant | — | Completed | — | — | — |
NCT06716307CT.gov A Research Study to Compare Blood Levels of Cagrilintide and Semaglutide After Single Doses of Different Versions of Injectable CagriSema in Adults With Overweight or Obesity | — | Completed | — | — | — |
NCT06616961CT.gov Efficacy and Safety of Semaglutide for Weight Loss in Overweight or Obese Adults in Bangladesh With or Without Type 2 Diabetes Mellitus | — | Not Yet Recruiting | — | — | — |
NCT06575738CT.gov Physiologic Response to Bariatric Surgery and the Impact of Adjunct Semaglutide in Adolescents | — | Recruiting | — | — | — |
NCT05202353CT.gov A Study in People With Obesity to Test the Effects of BI 456906 Compared With Semaglutide on Glucagon Receptor Activity in the Liver | — | Recruiting | — | — | — |
NCT07096063CT.gov Comparative Effectiveness of Tirzepatide and Semaglutide in Individuals at Cardiovascular Risk | — | Completed | — | — | — |
NCT06604624CT.gov Semaglutide in Treatment of Obesity | — | Completed | — | — | — |
NCT06577090CT.gov Study to Evaluate the Effect on Obesity of QW Nimacimab and QW Nimacimab Co-administered With Semaglutide vs Placebo | — | Active Not Recruiting | — | — | — |
NCT06184633CT.gov DUTCH Weight Control in Atrial Fibrillation Study | — | Recruiting | — | — | — |
NCT06492330CT.gov Efficacy and Safety of CS0159 Combined With Semaglutide in MASH Patients With Obesity and T2DM | — | Completed | — | — | — |
NCT06411210CT.gov Obesity Complicating Type 1 Diabetes: GLP-1 Analogue Anti-obesity Treatment | — | Recruiting | — | — | — |
NCT06388187CT.gov A Research Study to See How Well Different Doses of CagriSema Help People With Excess Body Weight Lose Weight | — | Completed | — | — | — |
NCT06500429CT.gov A Study to Evaluate the Safety and Efficacy of NG101 in Adult Participants Receiving a Glucagon-like Peptide-1 (GLP-1) Agonist | — | Completed | — | — | — |
NCT06423599CT.gov Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart Failure | — | Recruiting | — | — | — |
NCT06287307CT.gov Semaglutide 2.4mg for Low Responders After Bariatric Surgery | — | Not Yet Recruiting | — | — | — |
NCT06282458CT.gov Dose-Finding Study Evaluating Effect on Body Composition of Enobosarm in Patients Taking a GLP-1 for Chronic Weight Mgmt | — | Completed | — | — | — |
NCT06173778CT.gov Semaglutide for Post-Smoking Cessation Weight Management | — | Recruiting | — | — | — |
NCT06131372CT.gov A Research Study to See if Kidney Damage in People With Chronic Kidney Disease and Type 2 Diabetes Living With Overweight or Obesity Can be Reduced by CagriSema Compared to Semaglutide, Cagrilintide and Placebo | — | Completed | — | — | — |
NCT06299098CT.gov A Study to Test if Trevogrumab or Trevogrumab With Garetosmab When Taken With Semaglutide is Safe and How Well They Work in Adult Patients With Obesity for Weight Loss, Fat Loss, and Lean Mass Preservation | — | Active Not Recruiting | — | — | — |
NCT06289504CT.gov A Study on How CagriSema Affects Levels of Atorvastatin and Warfarin in the Blood of Participants With Excess Body Weight | — | Completed | — | — | — |
NCT06207877CT.gov A Research Study to Look at How CagriSema Influences Food Intake, Appetite and Emptying of the Stomach in People With Excess Body Weight | — | Completed | — | — | — |
NCT06234111CT.gov Semaglutide and Physical Activity for Obesity and Multimorbidity | — | Active Not Recruiting | — | — | — |
NCT06267092CT.gov A Study of How CagriSema Works on Appetite in People With Excess Body Weight | — | Completed | — | — | — |
NCT05746039CT.gov Feasibility of Semaglutide in Advanced Lung Disease | — | Recruiting | — | — | — |
NCT07336862CT.gov Bariatric Surgery Combined With GLP-1 Receptor Agonists Study | — | Recruiting | — | — | — |
NCT06131437CT.gov A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose Weight | — | Completed | — | — | — |
NCT05819853CT.gov Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome | — | Recruiting | — | — | — |
NCT05996848CT.gov A Research Study to See How Well CagriSema Helps People in China With Excess Body Weight Lose Weight | — | Completed | — | — | — |
NCT05756764CT.gov Anti-obesity Pharmacotherapy and Inflammation | — | Active Not Recruiting | — | — | — |
NCT05870462CT.gov Semaglutide and Vascular Regeneration | — | Unknown | — | — | — |
NCT05822830CT.gov A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities | — | Completed | — | — | — |
NCT05751226CT.gov A Study in People With Overweight or Obesity to Test How Well Different Doses of BI 1820237 Are Tolerated When Given Alone or in Combination With Either Semaglutide or BI 456906 | — | Completed | — | — | — |
NCT05813925CT.gov A Research Study to See How Well CagriSema Helps People in East Asia With Excess Body Weight Lose Weight | — | Completed | — | — | — |
NCT05786521CT.gov Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older Adults | — | Completed | — | — | — |
NCT06827002CT.gov Effect of Aqueous Extracts of Cissus Quadrangularis and Dichrostachys Glomerata on GLP-1 Concentration and DPP-4 Activity in Overweight and Obese Adults | — | Active Not Recruiting | — | — | — |
NCT05419726CT.gov Brown Adipose Tissue Activity in Response to Semaglutide Administered to Obese Subjects. | — | Recruiting | — | — | — |
NCT05394519CT.gov A Research Study to See How Well CagriSema Helps People With Type 2 Diabetes and Excess Body Weight Lose Weight | — | Completed | — | — | — |
NCT05671653CT.gov A Study to Evaluate the Effect of the Experimental GLP-1 Drug PF-07081532 on Blood Levels of Common Birth Control Pills, and Drugs Omeprazole and Midazolam, and Effect of GLP-1 Drug Semaglutide on Midazolam Blood Levels in Healthy Adults With Weight in the Obesity Range | — | Terminated | — | — | — |
NCT05087342CT.gov Latino Semaglutide Study | — | Completed | — | — | — |
NCT05616013CT.gov Safety and Efficacy of Bimagrumab and Semaglutide in Adults Who Are Overweight or Obese | — | Completed | — | — | — |
NCT05567796CT.gov A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight | — | Active Not Recruiting | — | — | — |
NCT04885634CT.gov Semaglutide for the Reduction of Arrhythmia Burden in Overweight AF Patients | — | Withdrawn | — | — | — |
NCT05340868CT.gov Genetics of the Acute Response to Oral Semaglutide | — | Recruiting | — | — | — |
NCT05302596CT.gov Semaglutide Use in Elderly Obese Patients | — | Completed | — | — | — |
NCT04998136CT.gov Research Study Investigating How Well Semaglutide Works in People From Thailand and South Korea Living With Obesity | — | Completed | — | — | — |
NCT05548647CT.gov Semaglutide Treatment, Appetite, and Eating Behavior: Long-term Effects | — | Completed | — | — | — |
NCT04174755CT.gov Semaglutide's Efficacy in Achieving Weight Loss for Those With HIV | — | Recruiting | — | — | — |
NCT05071898CT.gov Pharmacogenetics of Response to GLP1R Agonists | — | Recruiting | — | — | — |
NCT07457424CT.gov Direct Measurement of Microstructure of Ingestive Behaviour After Initiation of GLP-1 Receptor Agonist Treatment at Maximum Dose (DIGRAT) | — | Active Not Recruiting | — | — | — |
NCT05236517CT.gov A Research Study Looking at How 50 mg Semaglutide Daily Affects Food Intake and Emptying of the Stomach in People With Obesity | — | Completed | — | — | — |
NCT05078255CT.gov The Separate and Combined Effects of Long-term GIP and GLP-1 Receptor Activation in Patients with Type 2 Diabetes | — | Completed | — | — | — |
NCT05064735CT.gov Research Study Looking at How Well Semaglutide Works in People Suffering From Obesity and Knee Osteoarthritis | — | Completed | — | — | — |
NCT05040971CT.gov Research Study Looking at How Well Semaglutide Works in People Living With Obesity and Prediabetes | — | Completed | — | — | — |
NCT04741074CT.gov Effect of Subcutaneous Semaglutide on Kidney Transplant Candidacy | — | Terminated | — | — | — |
NCT04969939CT.gov A Research Study to Investigate How Well NNC0165-1875 in Combination With Semaglutide Works in People With Obesity | — | Completed | — | — | — |
NCT04940078CT.gov A Research Study to Compare Blood Levels of Cagrilintide and Semaglutide After Combined Versus Separate Injections in People With Overweight or Obesity | — | Completed | — | — | — |
NCT04779697CT.gov GLP-1 Analogue Effects on Food Cues, Stress, Motivation for Highly Palatable Foods, and Weight | — | Completed | — | — | — |
NCT04259801CT.gov First Research Study to Look at How Two Medicines, NNC0480-0389 and Semaglutide, Work Together in Healthy People, in People With High Body Weight and in People With Diabetes | — | Completed | — | — | — |
NCT04019197CT.gov Effects of Semaglutide in HIV-Associated Lipohypertrophy | — | Active Not Recruiting | — | — | — |
NCT03919929CT.gov Treating PCOS With Semaglutide vs Active Lifestyle Intervention | — | Completed | — | — | — |
NCT03292315CT.gov Once Weekly GLP-1 in Persons With Spinal Cord Injury | — | Completed | — | — | — |
NCT03707990CT.gov A Research Study of NNC0165-1875 Alone or Together With Semaglutide in People Who Are Overweight or Obese | — | Completed | — | — | — |
NCT03600480CT.gov A Research Study of How NNC0174-0833 Taken With Semaglutide Works in People Who Are Overweight or Obese | — | Completed | — | — | — |
NCT03574584CT.gov A Research Study of NNC0165-1562 and Semaglutide in People Who Are Overweight or Obese | — | Completed | — | — | — |
NCT03552757CT.gov Research Study Investigating How Well Semaglutide Works in People With Type 2 Diabetes Suffering From Overweight or Obesity | — | Completed | — | — | — |
NCT01922934CT.gov A Toolbox Approach to Obesity Treatment in Primary Care | — | Completed | — | — | — |
NCT06863363CT.gov PEG-rhGH and Semaglutide Combination Therapy in Non-Diabetic Obese Adults | — | Not Yet Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
59High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Obesity Disorder
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Semaglutide (this asset) | Ali Aminian | Approved | BBB · 72 |
| vi-0521 | VIVUS LLC | P4 | BBB |
| Tirzepatide | Royal North Shore Hospital | P4 | BBB |
| asc30 | Ascletis Pharma (China) Co., Limited | P2 | BBB |
| Phentermine | Russell McCulloh, MD | P4 | BBB |
| Survodutide | Boehringer Ingelheim | P3 | BBB |
| Deoxycholic Acid | University of California, San Diego | P4 | BBB |
| Efsubaglutide Alfa | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | P4 | BBB |
| Cagrilintide | Novo Nordisk A/S | P3 | BBB |
+42 more in the Obesity Disorder cohort
Other indications for Semaglutide
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Metabolic Disease | — | P4 | A · 81 |
| Polycystic Ovary Syndrome | — | P4 | BBB · 79 |
| Type 2 Diabetes Mellitus | — | P4 | BBB · 78 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Citation
Floatz Terminal. Semaglutide in Obesity Disorder. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 11, 2026. Accessed July 13, 2026. https://terminal.floatz.ai/assets/semaglutide-obesity-disorder
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