Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
Holland Bloorview Kids Rehabilitation Hospital
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06081348CT.gov Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Autism
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Sertraline (this asset) | Holland Bloorview Kids Rehabilitation Hospital | P2 | CCC · 53 |
| Lurasidone | Sumitomo Pharma America, Inc. | P3 | BB |
| Sirolimus | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | P2 | B |
| Everolimus | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | P2 | B |
| Cholesterol Suspension | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | P1/2 | CCC |
| Brexpiprazole | Otsuka Pharmaceutical Development & Commercialization, Inc. | P1 | CC |
| Fluoxetine | Icahn School of Medicine at Mount Sinai | N/A | D |
Other indications for Sertraline
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Anxiety Disorder | — | P4 | BBB · 76 |
| Psychotic Disorder | — | P4 | BBB · 74 |
| Depressive Disorder | — | P4 | BBB · 73 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
- LurasidoneSumitomo Pharma America, Inc.BB
- SirolimusHugo W. Moser Research Institute at Kennedy Krieger, Inc.B
- EverolimusHugo W. Moser Research Institute at Kennedy Krieger, Inc.B
- Cholesterol SuspensionEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)CCC
- BrexpiprazoleOtsuka Pharmaceutical Development & Commercialization, Inc.CC
Citation
Floatz Terminal. Sertraline in Autism. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/sertraline-autism
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