Silymarin
Metabolic Dysfunction-Associated Steatotic Liver Disease
Explore 131 assets in Metabolic Dysfunction-Associated Steatotic Liver Disease →Floatz Rating
BB69/100
Confidence
Indicative
Sponsor
University Hospitals Cleveland Medical Center
Modality
UNKNOWN
Development Phase
Phase 4 / Approved
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
67High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06477146CT.gov Milk Thistle Clinical Trial in Pediatric NAFLD | — | Recruiting | — | — | — |
NCT02973295CT.gov Silymarin in NAFLD | — | Withdrawn | — | — | — |
NCT05042245CT.gov The Efficacy and Safety of Ornithine Aspartic Acid Granules in NAFLD Against Silymarin Capsules | — | Completed | — | — | — |
NCT02006498CT.gov Silymarin for the Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) | — | Completed | — | — | — |
NCT00389376CT.gov Phase I Trial of Silymarin for Chronic Liver Diseases | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Metabolic Dysfunction-Associated Steatotic Liver Disease
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Silymarin (this asset) | University Hospitals Cleveland Medical Center | Approved | BB · 69 |
| Dapagliflozin | Post Graduate Institute of Medical Education and Research, Chandigarh | P4 | BBB |
| Metformin | Xiqiao Zhou | P4 | BBB |
| Exenatide | Fudan University | P4 | BBB |
| Empagliflozin | Justin Ryder | P4 | BBB |
| Pioglitazone | Badr University | P4 | BBB |
| Tirzepatide | Regeneron Pharmaceuticals | P3 | BBB |
| Clesacostat | Columbia University | P2 | BB |
| Ervogastat | Pfizer | P2 | BB |
+42 more in the Metabolic Dysfunction-Associated Steatotic Liver Disease cohort
Other indications for Silymarin
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Colorectal Cancer | — | P4 | B · 63 |
| Metabolic Dysfunction-Associated Steatohepatitis | — | P2 | B · 57 |
| Peripheral Neuropathy | — | P2/3 | B · 57 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Silymarin in Metabolic Dysfunction-Associated Steatotic Liver Disease. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/silymarin-metabolic-dysfunction-associated-steatotic-liver-disease
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