Floatz Rating
BB71/100
Confidence
Indicative
Sponsor
Mclean Hospital
Modality
Small molecule
Development Phase
Phase 4 / Approved
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
68High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT01602029CT.gov Randomized Double Blind Placebo Control Study in Patients with Schizophrenia | — | Completed | — | — | — |
NCT00672464CT.gov Cardio Risk of Acute Schizophrenia Olanzapine Duke | — | Withdrawn | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Schizoaffective Disorder
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Simvastatin (this asset) | Mclean Hospital | Approved | BB · 71 |
| Paliperidone | Luye Pharma Group Ltd. | P4 | BBB |
| Risperidone | Lyndra Inc. | P4 | BBB |
| Raloxifene | Iris Sommer | P4 | BBB |
| Lurasidone | University of Texas Southwestern Medical Center | P4 | BBB |
| Olanzapine | The Royal Ottawa Mental Health Centre | P4 | BBB |
| Quetiapine | Otsuka Pharmaceutical Development & Commercialization, Inc. | P4 | BBB |
| Dexmedetomidine | BioXcel Therapeutics Inc | P4 | BBB |
| Ziprasidone | Centre for Addiction and Mental Health | P4 | BBB |
+42 more in the Schizoaffective Disorder cohort
Other indications for Simvastatin
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Cirrhosis Of Liver | — | P4 | BBB · 72 |
| Abdominal Obesity-Metabolic Syndrome | — | P4 | BBB · 72 |
| Schizophrenia | — | P4 | BB · 70 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Simvastatin in Schizoaffective Disorder. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 14, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/simvastatin-schizoaffective-disorder
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