Floatz Rating
C36/100
Confidence
Indicative
Sponsor
Celgene
Modality
protein_peptide
Development Phase
Phase 2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
21Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT01571635CT.gov Study to Determine the Safety and Tolerability of Sotatercept (ACE-011) in Adults With Beta( β)- Thalassemia. | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Moderate confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Beta-Thalassemia Intermedia
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Sotatercept (this asset) | Celgene | P2 | C · 36 |
| Sodium 2,2 Dimethylbutyrate | Boston University | P2 | B |
| Mitapivat | Agios Pharmaceuticals, Inc. | P3 | B |
| Hydroxyurea | Shiraz University of Medical Sciences | P2 | CCC |
| L-Carnitine | Shiraz University of Medical Sciences | P2 | CCC |
| Vit-2763 Twice A Day | Vifor (International) Inc. | P2 | CCC |
| Vit-2763 Once A Day | Vifor (International) Inc. | P2 | CCC |
| Human Apotransferrin | Prothya Biosolutions | P2 | CCC |
| Sapablursen | Ionis Pharmaceuticals, Inc. | P2 | CCC |
+3 more in the Beta-Thalassemia Intermedia cohort
Other indications for Sotatercept
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Anemia | — | P2 | C · 36 |
| Plasma Cell Myeloma | — | P2 | C · 36 |
| Beta-Thalassemia Major | — | P2 | C · 36 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Sotatercept in Beta-Thalassemia Intermedia. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 14, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/sotatercept-beta-thalassemia-intermedia
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