Floatz Rating
C37/100
Confidence
Indicative
Sponsor
Shanghai Zhongshan Hospital
Modality
Small molecule
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05701553CT.gov Anti-PD-1/PD-L1 Antibodies Plus S-adenosyl-methionine Treatment in Patients With Advanced-Stage Hepatocellular Carcinoma | — | Unknown | — | — | — |
NCT03178929CT.gov Effect of SAMe Treatment on Recurrence After Radical Treatment of Primary Hepatic Carcinoma | — | Unknown | — | — | — |
NCT02586285CT.gov Effect of S-Adenosyl Methionine Treatment on Recurrence After Curative Resection of Hepatocellular Carcinoma | — | Unknown | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
65High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Hepatocellular Carcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| S,S-Adenosylmethionine (this asset) | Shanghai Zhongshan Hospital | P1 | C · 37 |
| Adriamycin | VA Office of Research and Development | P4 | BBB |
| Fluorouracilum | Li Qiang | P4 | BBB |
| Oxaliplatin | Li Qiang | P4 | BBB |
| Theprubicin | RWTH Aachen University | P4 | BBB |
| Iodized Ethyl Esters Of Poppyseed Fatty Acids | RWTH Aachen University | P4 | BBB |
| Lenvatinib | Zhejiang Haichang Biotech Co., Ltd. | P4 | BB |
| Epirubicin | Fudan University | P4 | BB |
| Adefovir | Bukwang Pharmaceutical | P4 | BB |
+42 more in the Hepatocellular Carcinoma cohort
Other indications for S,S-Adenosylmethionine
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Depressive Disorder | — | P2/3 | B · 62 |
| Hepatitis | — | P3 | B · 59 |
| Cirrhosis Of Liver | — | P2 | CCC · 52 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. S,S-Adenosylmethionine in Hepatocellular Carcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 14, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/ss-adenosylmethionine-hepatocellular-carcinoma
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