Synthetic Levothyroxine
Type 2 Diabetes Mellitus
Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
Duke-NUS Graduate Medical School
Modality
Small molecule
Development Phase
Phase 2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03281083CT.gov Levothyroxine for Non-Alcoholic Fatty Liver Disease (NAFLD) | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Type 2 Diabetes Mellitus
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Synthetic Levothyroxine (this asset) | Duke-NUS Graduate Medical School | P2 | CCC · 53 |
| Liraglutide | RenJi Hospital | P4 | BBB |
| Exenatide | Vivani Medical, Inc | P4 | BBB |
| Cotadutide | AstraZeneca | P2 | BBB |
| Dapagliflozin | Bhavya Bhavya, MD | P4 | BBB |
| Semaglutide | Shanghai Jiao Tong University School of Medicine | P4 | BBB |
| Metformin | Myopharm Limited | P4 | BBB |
| Saxagliptin | Nick Giannoukakis, PhD | P4 | BBB |
| Testosterone Undecylate | Alexandra Kautzky-Willer | P4 | BBB |
+41 more in the Type 2 Diabetes Mellitus cohort
Other indications for Synthetic Levothyroxine
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Hypothyroidism | — | P4 | BBB · 72 |
| Bipolar Disorder | — | P2/3 | CCC · 55 |
| Metabolic Dysfunction-Associated Steatotic Liver Disease | — | P2 | CCC · 55 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Citation
Floatz Terminal. Synthetic Levothyroxine in Type 2 Diabetes Mellitus. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 13, 2026. https://terminal.floatz.ai/assets/synthetic-levothyroxine-type-2-diabetes-mellitus
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