Tapentadol
Diabetic Neuropathy
Floatz Rating
BB65/100
Confidence
Indicative
Sponsor
Janssen Pharmaceutical K.K.
Modality
Small molecule
Development Phase
Phase 3
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
50High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT01124617CT.gov A Phase 2 Study of Tapentadol Extended-Release (JNS024ER) ) in Japanese Participants With Chronic Pain Due to Diabetic Neuropathic Pain or Postherpetic Neuralgia | — | Completed | — | — | — |
NCT01063868CT.gov A Long-term Safety Study With Tapentadol ER and Oxycodone CR in Patients With Moderate to Severe Pain Due to Chronic, Painful Diabetic Peripheral Neuropathy (DPN) | — | Terminated | — | — | — |
NCT01041859CT.gov A Study to Evaluate the Efficacy, Safety, and Tolerability of Tapentadol ER Compared With Placebo in Patients With Chronic, Painful Diabetic Peripheral Neuropathy | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Diabetic Neuropathy
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Tapentadol (this asset) | Janssen Pharmaceutical K.K. | P3 | BB · 65 |
| Duloxetine | Aga Khan University | P4 | A |
| Gabapentin | Aziende Chimiche Riunite Angelini Francesco S.p.A | P4 | BBB |
| Mirogabalin | Bangladesh Medical University | P4 | BBB |
| Capsaicin | Corporacion Parc Tauli | P4 | BBB |
| Pregabalin | Shandong Suncadia Medicine Co., Ltd. | P4 | BBB |
| Lidocaine | Corporacion Parc Tauli | P4 | BBB |
| (±)-2-(O-Chlorophenyl)-2-(Methylamino)Cyclohexanone | Irmandade da Santa Casa de Misericordia de Sao Paulo | P3 | BB |
| Mexiletine | National Center for Research Resources (NCRR) | P3 | BB |
+42 more in the Diabetic Neuropathy cohort
Other indications for Tapentadol
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Osteoarthritis | — | P4 | BB · 71 |
| Vertebral Column Disorder | — | P4 | BB · 67 |
| Chronic Pain Syndrome | — | P4 | BB · 65 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Citation
Floatz Terminal. Tapentadol in Diabetic Neuropathy. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 13, 2026. https://terminal.floatz.ai/assets/tapentadol-diabetic-neuropathy
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