Floatz Rating
CC43/100
Confidence
Indicative
Sponsor
Centre Hospitalier Universitaire de Nīmes
Modality
Small molecule
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06650800CT.gov Effect of Psilocybin on the Positive Valence System in Treatment-resistant Depression | — | Completed | — | — | — |
NCT06442423CT.gov Open-Label Psilocybin Study in Transdiagnostic Population | — | Recruiting | — | — | — |
NCT07164287CT.gov Retrospective Observational Study of Intensity Effects in Psychedelic-assisted Treatment | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Substance-Related Disorder
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Teonanacatl (this asset) | Centre Hospitalier Universitaire de Nīmes | P1 | CC · 43 |
| Methadone | Rutgers, The State University of New Jersey | P4 | BBB |
| Hydromorphon | Endeavor Health | P4 | BBB |
| (±)-2-(O-Chlorophenyl)-2-(Methylamino)Cyclohexanone | Wake Forest University Health Sciences | P4 | BBB |
| Fentanyl | University of Crete | P4 | BB |
| Dexmedetomidine | Kaohsiung Veterans General Hospital. | P4 | BB |
| Oxycodone | Wake Forest University Health Sciences | P4 | BB |
| Lidocaine | Tanta University | P4 | BB |
| Nepenthe | Samsun University | P4 | BB |
+18 more in the Substance-Related Disorder cohort
Other indications for Teonanacatl
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Depressive Disorder | — | P2 | BB · 68 |
| Hematopoietic And Lymphoid System Neoplasm | — | P2 | BB · 65 |
| Major Depressive Disorder | — | P3 | BB · 65 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Teonanacatl in Substance-Related Disorder. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/teonanacatl-substance-related-disorder
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