Floatz Rating
B57/100
Confidence
Indicative
Sponsor
Chang Gung Memorial Hospital
Modality
Small molecule
Development Phase
Phase 2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
42Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04572477CT.gov The Influence of Sequential Tau Protein and Amyloid Plaque Imaging Changes on Stroke Prognosis and Cognitive Outcome | — | Unknown | — | — | — |
NCT04588649CT.gov The Aging Brain and Cognition: Contribution of Vascular Injury, Amyloid Plaque and Tau Protein to Cognitive Dysfunction After Stroke | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Vascular Dementia
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Thk-5351 (this asset) | Chang Gung Memorial Hospital | P2 | B · 57 |
| Pittsburgh Compound B Unlabelled | National Taiwan University Hospital | P4 | BB |
| Cilostazol | Peking University First Hospital | P4 | BB |
| Risperidone | Janssen-Cilag Pty Ltd | P3 | BB |
| Oxycodone Hydrochloride, Hydrocodone- | VA Office of Research and Development | P4 | BB |
| Aspirin | Peking University First Hospital | P4 | BB |
| Rivastigmine | Novartis | P3 | BB |
| Choline Alfoscerate | Chong Kun Dang Pharmaceutical | P4 | BB |
| Atorvastatin | Monash University | P4 | BB |
+32 more in the Vascular Dementia cohort
Other indications for Thk-5351
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Alzheimer Disease | — | P2 | B · 58 |
| Neurodegenerative Disease | — | P2 | B · 57 |
| Cognitive Disorder | — | P2 | CCC · 54 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Thk-5351 in Vascular Dementia. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/thk-5351-vascular-dementia-116725
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