Floatz Rating
CCC48/100
Confidence
Indicative
Sponsor
Tango Therapeutics, Inc.
Modality
UNKNOWN
Development Phase
Phase 1/2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
33Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06810544CT.gov Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Moderate confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Lung Adenocarcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| tng456 (this asset) | Tango Therapeutics, Inc. | P1/2 | CCC · 48 |
| Carboplatin | Guangdong Association of Clinical Trials | P3 | BBB |
| Cyclophosphamide | Anusha Kalbasi | P2 | BBB |
| Etoposide | Guangdong Association of Clinical Trials | P3 | BB |
| Nivolumab | Emory University | P3 | BB |
| Cis-Diamminedichloroplatinum Ii | Guangdong Association of Clinical Trials | P3 | BB |
| Docetaxel | Sichuan Baili Pharmaceutical Co., Ltd. | P3 | BB |
| Osimertinib | Shanghai Chest Hospital | P2 | BB |
| Vinorelbine Ditartrate | AIO-Studien-gGmbH | P3 | BB |
+42 more in the Lung Adenocarcinoma cohort
Other indications for tng456
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Glioblastoma | — | P1/2 | CCC · 48 |
| Malignant Glioma | — | P1/2 | CC · 45 |
| Brain Neoplasm | — | P1/2 | CC · 45 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. tng456 in Lung Adenocarcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/tng456-lung-adenocarcinoma
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