Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
National Institute of Respiratory Diseases, Mexico
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05246293CT.gov Tofacitinib in the Treatment of Rheumatoid Arthritis-related Interstitial Lung Disease. | — | Unknown | — | — | — |
NCT04175886CT.gov Effects of Tofacitinib on Body Composition, Bone Mineral Density and Bone Marrow Adiposity in Patients With Rheumatoid Arthritis: the TOFAT Project | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Rheumatoid Arthritis
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Tofacitinib (this asset) | National Institute of Respiratory Diseases, Mexico | P2 | CCC · 53 |
| Naltrexone | Truway Health, Inc. | P4 | BBB |
| Ibuprofen | Amgen | P3 | BB |
| Methotrexate | National Institute of Allergy and Infectious Diseases (NIAID) | P3 | BB |
| Buprenorphine | Mundipharma Pte Ltd. | P4 | BB |
| Tocilizumab | Hoffmann-La Roche | P3 | BB |
| Prednisone | Hoffmann-La Roche | P3 | BB |
| Olokizumab | R-Pharm International, LLC | P3 | BB |
| nc-503 | Bellus Health Inc. - a GSK company | P2/3 | B |
+30 more in the Rheumatoid Arthritis cohort
Other indications for Tofacitinib
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Psoriasis | — | P2 | B · 57 |
| Glioblastoma | — | P3 | CCC · 54 |
| Interstitial Lung Disease | — | P2 | CCC · 53 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Tofacitinib in Rheumatoid Arthritis. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/tofacitinib-rheumatoid-arthritis
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