Floatz Rating
BB67/100
Confidence
Indicative
Sponsor
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Modality
Small molecule
Development Phase
Phase 3
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
53High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT00035802CT.gov A Study to Evaluate the Safety and Effectiveness of Topiramate Compared to Placebo in the Treatment of Patients With Bipolar I Disorder | — | Completed | — | — | — |
NCT00240721CT.gov A Study of the Effectiveness and Safety of Topiramate in the Treatment of Patients With Bipolar Disorder | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Mood Disorder
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Topiramate (this asset) | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | P3 | BB · 67 |
| Brexpiprazole | Otsuka Pharmaceutical Development & Commercialization, Inc. | P3 | BBB |
| Olanzapine | University of Ghana Medical School | P4 | BBB |
| Fluoxetine | University of Ghana Medical School | P4 | BBB |
| Minocycline | Pakistan Institute of Living and Learning | P4 | BBB |
| Paliperidone | Luye Pharma Group Ltd. | P3 | BB |
| Quetiapine | First Affiliated Hospital of Zhejiang University | P4 | BB |
| Amitryptaline | University of Ghana Medical School | P4 | BB |
| Risperidone | University of Ghana Medical School | P4 | BB |
+25 more in the Mood Disorder cohort
Other indications for Topiramate
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Focal Epilepsy | — | P4 | A · 80 |
| Migraine With Aura | — | P4 | BBB · 78 |
| Migraine Without Aura | — | P4 | BBB · 78 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Topiramate in Mood Disorder. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/topiramate-mood-disorder
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