Floatz Rating
B58/100
Confidence
Indicative
Sponsor
National Cancer Institute (NCI)
Modality
UNKNOWN
Development Phase
Phase 1
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
48High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT00390052CT.gov 3-AP in Treating Patients With Advanced or Metastatic Solid Tumors | — | Completed | — | — | — |
NCT00293345CT.gov 3-AP and Gemcitabine in Treating Patients With Advanced Solid Tumors or Lymphoma | — | Completed | — | — | — |
NCT00084877CT.gov Irinotecan and 3-AP in Treating Patients With Metastatic or Unresectable Solid Tumors | — | Completed | — | — | — |
NCT00079014CT.gov 3-AP and Doxorubicin In Treating Patients With Metastatic or Refractory Solid Tumors | — | Completed | — | — | — |
NCT00024323CT.gov Combination Chemotherapy in Treating Patients With Advanced Cancer | — | Completed | — | — | — |
NCT00016874CT.gov 3-AP Plus Cisplatin and Paclitaxel in Treating Patients With Advanced or Metastatic Cancer | — | Completed | — | — | — |
NCT00006218CT.gov 3-AP in Treating Patients With Advanced Cancer | — | Completed | — | — | — |
NCT00004213CT.gov 3-Aminopyridine-2-carboxaldehyde Thiosemicarbazone in Treating Patients With Solid Tumors | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Cancer Of Unknown Primary Site
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Triapine (this asset) | National Cancer Institute (NCI) | P1 | B · 58 |
| Amifostine | M.D. Anderson Cancer Center | P4 | BBB |
| Nepenthe | M.D. Anderson Cancer Center | P4 | BBB |
| Dexasone | Alliance for Clinical Trials in Oncology | P3 | BBB |
| Etoposide | University of California, Davis | P2/3 | BBB |
| Irinotecan | University of Chicago | P2 | BBB |
| Sargramostim | Barbara Ann Karmanos Cancer Institute | P2 | BBB |
| Melphalan | City of Hope Medical Center | P2/3 | BBB |
| Cyclophosphamide | M.D. Anderson Cancer Center | P3 | BBB |
+42 more in the Cancer Of Unknown Primary Site cohort
Other indications for Triapine
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Ovarian Carcinoma | — | P2 | BB · 64 |
| Malignant Pancreatic Neoplasm | — | P2 | BB · 64 |
| Pancreatic Acinar Cell Carcinoma | — | P2 | B · 57 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Triapine in Cancer Of Unknown Primary Site. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/triapine-cancer-of-unknown-primary-site
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