Floatz Rating
BB64/100
Confidence
Indicative
Sponsor
VA Office of Research and Development
Modality
Small molecule
Development Phase
Phase 3
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
56High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT01342549CT.gov Treatment Strategy for Alcohol Use Disorders in Veterans With TBI | — | Completed | — | — | — |
NCT01760785CT.gov Valproate for Mood Swings and Alcohol Use Following Head Injury | — | Completed | — | — | — |
NCT00114686CT.gov Efficacy and Safety of Quetiapine Fumarate (SEROQUEL®) in the Treatment of Alcohol Dependency in Patients With Bipolar Disorder | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Alcohol Dependence
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Valproic Acid (this asset) | VA Office of Research and Development | P3 | BB · 64 |
| Naltrexone | Inventage Lab., Inc. | P4 | BBB |
| Acamprosate | Hanyang University Seoul Hospital | P4 | BBB |
| Escitalopram | University of Texas Southwestern Medical Center | P4 | BBB |
| Topiramate | Stanford University | P4 | BB |
| Fluoxetine | New York State Psychiatric Institute | P4 | BB |
| Lamotrigine | Medical University of South Carolina | P4 | BB |
| Quetiapine | University of Texas Southwestern Medical Center | P4 | BB |
| Varenicline | State University of New York - Upstate Medical University | P4 | BB |
+18 more in the Alcohol Dependence cohort
Other indications for Valproic Acid
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Bipolar Disorder | — | P4 | BBB · 73 |
| Epilepsy | — | P4 | BBB · 73 |
| Bipolar I Disorder | — | P4 | BBB · 72 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Valproic Acid in Alcohol Dependence. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 13, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/valproic-acid-alcohol-dependence
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