Veliparib
Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative
Explore 11 assets in Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative →Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
National Cancer Institute (NCI)
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03289910CT.gov Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic Leukemia | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Veliparib (this asset) | National Cancer Institute (NCI) | P2 | CCC · 53 |
| Fludarabine | Fred Hutchinson Cancer Center | P2 | BB |
| Sirolimus | OHSU Knight Cancer Institute | P2 | B |
| Cyclosporin A | Fred Hutchinson Cancer Center | P2 | B |
| Tacrolimus | Fred Hutchinson Cancer Center | P2 | B |
| Carboplatin | OHSU Knight Cancer Institute | P2 | B |
| Ruxolitinib | St. Petersburg State Pavlov Medical University | P2 | B |
| Cyclophosphamide | Fred Hutchinson Cancer Center | P2 | B |
| Busulfanum | Fred Hutchinson Cancer Center | P2 | B |
+42 more in the Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative cohort
Other indications for Veliparib
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Non-Small Cell Lung Carcinoma | — | P3 | BBB · 74 |
| Small Cell Lung Carcinoma | — | P2 | BB · 71 |
| Triple-Negative Breast Carcinoma | — | P3 | BB · 69 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Veliparib in Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/veliparib-atypical-chronic-myeloid-leukemia-bcr-abl1-negative
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