Floatz Rating
CCC48/100
Confidence
Indicative
Sponsor
M.D. Anderson Cancer Center
Modality
Small molecule
Development Phase
Phase 1/2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
33Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03862157CT.gov Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Acquired Polycythemia Vera
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Venetoclax (this asset) | M.D. Anderson Cancer Center | P1/2 | CCC · 48 |
| Ruxolitinib | University of Washington | P4 | BB |
| Tacrolimus | Thomas Jefferson University | P2 | BB |
| Pegylated-Proline-Interferon Alpha-2B | AOP Orphan Pharmaceuticals AG | P3 | BB |
| Fludarabine | Thomas Jefferson University | P2 | BB |
| Cyclophosphamide | Thomas Jefferson University | P2 | BB |
| Therapeutic Allogeneic Lymphocytes | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | P2 | BB |
| Busulfanum | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | P2 | B |
| Panobinostat | Novartis Pharmaceuticals | P4 | B |
+28 more in the Acquired Polycythemia Vera cohort
Other indications for Venetoclax
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma | — | P4 | BB · 70 |
| Acute Myeloid Leukemia | — | P4 | BB · 69 |
| Chronic Myelomonocytic Leukemia | — | P2/3 | BB · 68 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Venetoclax in Acquired Polycythemia Vera. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/venetoclax-acquired-polycythemia-vera
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