Vistusertib
Estrogen-Receptor Negative Breast Cancer
Explore 19 assets in Estrogen-Receptor Negative Breast Cancer →Floatz Rating
CC43/100
Confidence
Indicative
Sponsor
M.D. Anderson Cancer Center
Modality
Small molecule
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT02208375CT.gov mTORC1/2 Inhibitor AZD2014 or the Oral AKT Inhibitor AZD5363 for Recurrent Endometrial and Ovarian | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Estrogen-Receptor Negative Breast Cancer
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Vistusertib (this asset) | M.D. Anderson Cancer Center | P1 | CC · 43 |
| Carboplatin | Northwestern University | P3 | BBB |
| Pembrolizumab | Massachusetts General Hospital | P2 | BB |
| Cis-Diamminedichloroplatinum Ii | University of Washington | P3 | BB |
| Epirubicin | Massachusetts General Hospital | P2 | BB |
| Irinotecan | Sanofi | P3 | BB |
| Cyclophosphamide | Massachusetts General Hospital | P3 | BB |
| Adriamycin | Roswell Park Cancer Institute | P3 | BB |
| Capecitabine | Kristina A. Fanucci | P3 | BB |
+42 more in the Estrogen-Receptor Negative Breast Cancer cohort
Other indications for Vistusertib
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Diffuse Large B-Cell Lymphoma | — | P2 | B · 62 |
| Small Cell Lung Carcinoma | — | P2 | B · 56 |
| Breast Cancer | — | P2 | B · 56 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Vistusertib in Estrogen-Receptor Negative Breast Cancer. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/vistusertib-estrogen-receptor-negative-breast-cancer
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