Floatz Rating
C32/100
Confidence
Indicative
Sponsor
MacroGenics
Modality
UNKNOWN
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
17Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05293496CT.gov A Study of MGC018 in Combination With MGD019 in Participants With Advanced Solid Tumors | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Hepatocellular Carcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Vobramitamab Duocarmazine (this asset) | MacroGenics | P1 | C · 32 |
| Adriamycin | VA Office of Research and Development | P4 | BBB |
| Fluorouracilum | Li Qiang | P4 | BBB |
| Oxaliplatin | Li Qiang | P4 | BBB |
| Theprubicin | RWTH Aachen University | P4 | BBB |
| Iodized Ethyl Esters Of Poppyseed Fatty Acids | RWTH Aachen University | P4 | BBB |
| Lenvatinib | Zhejiang Haichang Biotech Co., Ltd. | P4 | BB |
| Epirubicin | Fudan University | P4 | BB |
| Adefovir | Bukwang Pharmaceutical | P4 | BB |
+42 more in the Hepatocellular Carcinoma cohort
Other indications for Vobramitamab Duocarmazine
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Castration-Resistant Prostate Carcinoma | — | P2 | CC · 44 |
| Melanoma | — | P2 | CC · 42 |
| Head And Neck Squamous Cell Carcinoma | — | P2 | CC · 40 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Vobramitamab Duocarmazine in Hepatocellular Carcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 14, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/vobramitamab-duocarmazine-hepatocellular-carcinoma
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