Vobramitamab Duocarmazine
Oral Cavity Squamous Cell Carcinoma
Explore 11 assets in Oral Cavity Squamous Cell Carcinoma →Floatz Rating
C36/100
Confidence
Indicative
Sponsor
MacroGenics
Modality
UNKNOWN
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
21Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05551117CT.gov A Study of Vobramitamab Duocarmazine in Participants With Metastatic Castration Resistant Prostate Cancer and Other Solid Tumors | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Moderate confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Oral Cavity Squamous Cell Carcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Vobramitamab Duocarmazine (this asset) | MacroGenics | P2 | C · 36 |
| Cetuximab | National Cancer Institute (NCI) | P1/2 | B |
| Irinotecan | AIDS Malignancy Consortium | P1/2 | B |
| Carboplatin | Rapa Therapeutics LLC | P1/2 | B |
| Enzalutamide | MacroGenics | P2 | CCC |
| Cabozantinib | National Cancer Institute (NCI) | P2 | CCC |
| Abiraterone | MacroGenics | P2 | CCC |
| Nivolumab | National Cancer Institute (NCI) | P2 | CCC |
| Autologous Rapamycin-Resistant Th1/Tc1 Cells Rapa-201 | Rapa Therapeutics LLC | P1/2 | CCC |
+14 more in the Oral Cavity Squamous Cell Carcinoma cohort
Other indications for Vobramitamab Duocarmazine
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Melanoma | — | P2 | CC · 44 |
| Castration-Resistant Prostate Carcinoma | — | P2 | CC · 44 |
| Head And Neck Squamous Cell Carcinoma | — | P2 | CC · 40 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Vobramitamab Duocarmazine in Oral Cavity Squamous Cell Carcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/vobramitamab-duocarmazine-oral-cavity-squamous-cell-carcinoma
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