Vorinostat
Childhood Cerebellar Astrocytic Neoplasm
Floatz Rating
CCC51/100
Confidence
Indicative
Sponsor
National Cancer Institute (NCI)
Modality
Small molecule
Development Phase
Phase 1
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
36High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT01076530CT.gov Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors | — | Completed | — | — | — |
NCT00994500CT.gov Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Childhood Cerebellar Astrocytic Neoplasm
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Vorinostat (this asset) | National Cancer Institute (NCI) | P1 | CCC · 51 |
| Oxaliplatin | National Cancer Institute (NCI) | P2 | B |
| Irinotecan | National Cancer Institute (NCI) | P2 | B |
| Cilengitide | National Cancer Institute (NCI) | P2 | B |
| 2 (1H))-QUINOLINONE,6-(AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL)-4-(3-CHLOROPHENYL)-1-METHYL-,(+)- | National Cancer Institute (NCI) | P2 | CCC |
| Dexasone | National Cancer Institute (NCI) | P1 | CCC |
| Nivestim | City of Hope Medical Center | P1 | CCC |
| Romidepsin | City of Hope Medical Center | P1 | CCC |
| Veliparib | National Cancer Institute (NCI) | P1 | CC |
+11 more in the Childhood Cerebellar Astrocytic Neoplasm cohort
Other indications for Vorinostat
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Mantle Cell Lymphoma | — | P2 | BB · 64 |
| Follicular Lymphoma | — | P2 | BB · 64 |
| Acute Myeloid Leukemia | — | P3 | B · 63 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
- OxaliplatinNational Cancer Institute (NCI)B
- IrinotecanNational Cancer Institute (NCI)B
- CilengitideNational Cancer Institute (NCI)B
- 2 (1H))-QUINOLINONE,6-(AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL)-4-(3-CHLOROPHENYL)-1-METHYL-,(+)-National Cancer Institute (NCI)CCC
- DexasoneNational Cancer Institute (NCI)CCC
Citation
Floatz Terminal. Vorinostat in Childhood Cerebellar Astrocytic Neoplasm. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 14, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/vorinostat-childhood-cerebellar-astrocytic-neoplasm
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