Floatz Rating
CC43/100
Confidence
Indicative
Sponsor
Xencor, Inc.
Modality
UNKNOWN
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06276491CT.gov Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Moderate confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Ovarian Germ Cell Tumor
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Xmab541 (this asset) | Xencor, Inc. | P1 | CC · 43 |
| Etoposide | Nabil Adra | P3 | BB |
| Cis-Diamminedichloroplatinum Ii | Children's Oncology Group | P3 | BB |
| Metformin | University of Chicago | P2 | BB |
| Carboplatin | Case Comprehensive Cancer Center | P2 | BB |
| Bleomycin | Children's Oncology Group | P3 | BB |
| Nivestim | Children's Oncology Group | P2 | B |
| Oxaliplatin | National Cancer Institute (NCI) | P2 | B |
| Ipilimumab | National Cancer Institute (NCI) | P2 | B |
+36 more in the Ovarian Germ Cell Tumor cohort
Other indications for Xmab541
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Germ Cell Tumor | — | P1 | CC · 43 |
| Testicular Germ Cell Tumor | — | P1 | CC · 43 |
| Endometrial Carcinoma | — | P1 | C · 37 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Xmab541 in Ovarian Germ Cell Tumor. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/xmab541-ovarian-germ-cell-tumor
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