Floatz Rating
CCC48/100
Confidence
Indicative
Sponsor
BicycleTx Limited
Modality
protein_peptide
Development Phase
Phase 1/2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
33Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04561362CT.gov Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Malignancies | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Moderate confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Urinary Bladder Neoplasm
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Zelenectide Pavedotin (this asset) | BicycleTx Limited | P1/2 | CCC · 48 |
| Carboplatin | Merck Sharp & Dohme LLC | P2 | BB |
| Cis-Diamminedichloroplatinum Ii | Merck Sharp & Dohme LLC | P2 | BB |
| Enfortumab Vedotin (Fully Human Monoclonal Antibody Conjugated To A Cytotoxic Agent Monomethyl Auristatin E (Mmae) Targeting Nectin-4) | Eli Lilly and Company | P2 | BB |
| Pembrolizumab | Eli Lilly and Company | P2 | BB |
| Nivolumab | Ikena Oncology | P2 | B |
| Tetrahydrouridine | National Cancer Institute (NCI) | P2 | B |
| 5-fluoro-2-deoxycytidine | National Cancer Institute (NCI) | P2 | B |
| Capecitabine | Merck Sharp & Dohme LLC | P2 | B |
+28 more in the Urinary Bladder Neoplasm cohort
Other indications for Zelenectide Pavedotin
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Non-Small Cell Lung Carcinoma | — | P2 | CCC · 50 |
| Ovarian Neoplasm | — | P1/2 | CCC · 48 |
| Triple-Negative Breast Carcinoma | — | P1/2 | CC · 47 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
- CarboplatinMerck Sharp & Dohme LLCBB
- Cis-Diamminedichloroplatinum IiMerck Sharp & Dohme LLCBB
- Enfortumab Vedotin (Fully Human Monoclonal Antibody Conjugated To A Cytotoxic Agent Monomethyl Auristatin E (Mmae) Targeting Nectin-4)Eli Lilly and CompanyBB
- PembrolizumabEli Lilly and CompanyBB
- NivolumabIkena OncologyB
Citation
Floatz Terminal. Zelenectide Pavedotin in Urinary Bladder Neoplasm. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/zelenectide-pavedotin-urinary-bladder-neoplasm
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