Floatz Rating
B63/100
Confidence
Indicative
Sponsor
National Cancer Institute (NCI)
Modality
UNKNOWN
Development Phase
Phase 2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
48High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT00650923CT.gov Aflibercept, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma Multiforme, Gliosarcoma, or Other Malignant Glioma | — | Completed | — | — | — |
NCT00369590CT.gov VEGF Trap in Treating Patients With Recurrent Malignant Gliomas That Did Not Respond to Temozolomide | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Anaplastic Astrocytoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Ziv-Aflibercept (this asset) | National Cancer Institute (NCI) | P2 | B · 63 |
| Cediranib | National Cancer Institute (NCI) | P2 | BBB |
| Irinotecan | City of Hope Medical Center | P2/3 | BBB |
| (+)-Vincristine | Novartis Pharmaceuticals | P2/3 | BB |
| Carboplatin | Oliver Jonas | P2 | BB |
| Trametinib | National Cancer Institute (NCI) | P4 | BB |
| Cintredekin Besudotox | INSYS Therapeutics Inc | P1/2 | BB |
| Lomustine | M.D. Anderson Cancer Center | P3 | B |
| Cetuximab | University of Miami | P2 | B |
+42 more in the Anaplastic Astrocytoma cohort
Other indications for Ziv-Aflibercept
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Ovarian Carcinoma | — | P2 | BB · 69 |
| Melanoma | — | P2 | BB · 66 |
| Cutaneous Melanoma | — | P2 | B · 63 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Ziv-Aflibercept in Anaplastic Astrocytoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/ziv-aflibercept-anaplastic-astrocytoma
Are you the sponsor?
Submit your data room for a Verified Rating. The public-data rating remains visible alongside.
Contact →