Floatz Rating
B57/100
Confidence
Indicative
Sponsor
National Cancer Institute (NCI)
Modality
UNKNOWN
Development Phase
Phase 2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
42Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT00407485CT.gov VEGF Trap in Treating Patients With Recurrent, Locally Advanced, or Metastatic Cancer of the Urothelium | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Bladder Adenocarcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Ziv-Aflibercept (this asset) | National Cancer Institute (NCI) | P2 | B · 57 |
| Cabozantinib | National Cancer Institute (NCI) | P2 | CCC |
| Enfortumab Vedotin (Fully Human Monoclonal Antibody Conjugated To A Cytotoxic Agent Monomethyl Auristatin E (Mmae) Targeting Nectin-4) | Emory University | P2 | CCC |
| Nivolumab | National Cancer Institute (NCI) | P2 | CCC |
| Atezolizumab | National Cancer Institute (NCI) | P2 | CCC |
| Sorafenib | National Cancer Institute (NCI) | P2 | CCC |
| Pembrolizumab | Emory University | P2 | CCC |
| Ipilimumab | National Cancer Institute (NCI) | P2 | CCC |
Other indications for Ziv-Aflibercept
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Ovarian Carcinoma | — | P2 | BB · 69 |
| Melanoma | — | P2 | BB · 66 |
| Cutaneous Melanoma | — | P2 | B · 63 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
- CabozantinibNational Cancer Institute (NCI)CCC
- Enfortumab Vedotin (Fully Human Monoclonal Antibody Conjugated To A Cytotoxic Agent Monomethyl Auristatin E (Mmae) Targeting Nectin-4)Emory UniversityCCC
- NivolumabNational Cancer Institute (NCI)CCC
- AtezolizumabNational Cancer Institute (NCI)CCC
- SorafenibNational Cancer Institute (NCI)CCC
Citation
Floatz Terminal. Ziv-Aflibercept in Bladder Adenocarcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/ziv-aflibercept-bladder-adenocarcinoma
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