Zoledronate
Lewy Body Dementia
Floatz Rating
BB66/100
Confidence
Indicative
Sponsor
California Pacific Medical Center Research Institute
Modality
Small molecule
Development Phase
Phase 4 / Approved
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
51Moderate confidence
Detailed axis rationale is planned and will be published soon.
No trial-level evidence is linked to this axis yet.
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Lewy Body Dementia
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Zoledronate (this asset) | California Pacific Medical Center Research Institute | Approved | BB · 66 |
| Memantine | Zealand University Hospital | P4 | BBB |
| 6H-BENZOFURO(3A,3,2-EF)(2)BENZAZEPIN-6-OL, 4A,5,9,10,11,12-HEXAHYDRO-3-METHOXY-11-METHYL-, (4AS,6R,8AS) | Virginia Commonwealth University | P4 | BB |
| Dapagliflozin | Mayo Clinic | P4 | BB |
| Sitagliptin | Mayo Clinic | P4 | BB |
| Armodafinil | NYU Langone Health | P4 | BB |
| Intepirdine | Axovant Sciences Ltd. | P2/3 | BB |
| Irsenontrine | Eisai Inc. | P2 | BB |
| Neflamapimod | EIP Pharma Inc | P2 | BB |
+41 more in the Lewy Body Dementia cohort
Other indications for Zoledronate
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Metastatic Carcinoma In The Bone | — | P4 | BBB · 79 |
| Osteoporosis | — | P4 | BBB · 76 |
| Breast Carcinoma | — | P4 | BBB · 75 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Citation
Floatz Terminal. Zoledronate in Lewy Body Dementia. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 13, 2026. https://terminal.floatz.ai/assets/zoledronate-lewy-body-dementia
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