Floatz Rating
BB68/100
Confidence
Indicative
Sponsor
Biogen
Modality
Small molecule
Development Phase
Phase 3
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
54High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04442503CT.gov A Study to Evaluate the Efficacy and Safety of SAGE-217 in Participants With Severe Postpartum Depression (PPD) | — | Completed | — | — | — |
NCT02978326CT.gov A Study to Evaluate SAGE-217 in Participants With Severe Postpartum Depression | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Indicative
Detailed axis rationale is planned and will be published soon.
Same indication · Postpartum Depression
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Zuranolone (this asset) | Biogen | P3 | BB · 68 |
| Allopregnan-3.Alpha.-Ol-20-One | Supernus Pharmaceuticals, Inc. | P3 | BBB |
| Sertraline | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | P4 | BB |
| Gabapentin | Stanford University | P4 | BB |
| Escitalopram | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | P3 | BB |
| Lpcn 1154A | Lipocine Inc. | P3 | BB |
| Celecoxib | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | P3 | B |
| (±)-2-(O-Chlorophenyl)-2-(Methylamino)Cyclohexanone | Grace Lim, MD, MS | P2 | B |
| Nora520 | DuKang Pharmaceuticals, Inc. | P2 | B |
+4 more in the Postpartum Depression cohort
Other indications for Zuranolone
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Major Depressive Disorder | — | P3 | BB · 67 |
| Insomnia | — | P3 | B · 60 |
| Bipolar I Disorder | — | P2 | B · 57 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
- Allopregnan-3.Alpha.-Ol-20-OneSupernus Pharmaceuticals, Inc.BBB
- SertralineLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sBB
- GabapentinStanford UniversityBB
- EscitalopramLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sBB
- Lpcn 1154ALipocine Inc.BB
Citation
Floatz Terminal. Zuranolone in Postpartum Depression. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/zuranolone-postpartum-depression
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