203 assets in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Baff-R Car-T

bn102

Carcik-Cd19

gb261

Idp-121

Prednisolone

prt2527

Olaparib

Car-20/19-T Cells

C-Car066

Autologous Anti-Cd19 Car-Expressing T-Lymphocytes Ic19/1563

Autologous Baffr-Targeting Car T Cells

Autologous Cd19Car-Cd28-Cd3Zeta-Egfrt-Expressing Tcm-Enriched T Cells

Autologous Cd19Car-Cd28-Cd3Zeta-Egfrt-Expressing Tn/Mem-Enriched T-Lymphocytes

Baff Car-T

Besufetamig

Bgb-21447

BP1002

Cap-100

Chimeric Antigen Receptor Modified T Cells Infusion

Egfrt/19-28Z/4-1Bbl Car T Cells

Egfrt/19-28Z/Il-12 Car T-Lymphocytes

exs73565

Hmpl-760

Kur-502

Mb-Cart19.1

Pevonedistat

psb202

q702

Stk-009

Syncar-001

Tbi-2001

Ub-Vv111

xl114

Zandelisib

ze 50-0134

Zelebrudomide

Autologous T Cells Obtained From Peripheral Blood Mononuclear Cells By Leukapheresis, Transduced With A Self-Inactivating, Nonreplicating Lentiviral Vector, Encoding A T Cell Chimeric Antigen Receptor Targeting Cd19. The Expressed Transgene Comprises A Cd8? Leader Sequence, A Murine Anti-Cd19 Single Chain Variable Fragment (Scfv) Derived From The Mouse Hybridoma Fmc63, A Cd8? Hinge And Transmembrane Region, And A 4-1Bb (Cd137) And Cd3? (Tcr?) Signaling Domain And Is Under Control Of The Elongation Factor 1 Alpha (Ef1?) Promoter. The Construct Is Flanked By 5' And 3' Long Terminal Repeats (Ltrs) And Also Contains A ? Packaging Signal, A Rev Response Element (Rre), A Central Polypurine Tract (Cppt) Sequence And An Optimized Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element (Wpre). The Leukapheresis Material Is Enriched For Cd4/Cd8 T Cells By Positive Immunoselection, Activated By Cd3 And Cd28 Agonists And Transduced With The Vector. Without Further Cell Propagation, The T Cells Are Washed, Formulated For Infusion, And Cryopreserved. The Substance Is Composed Of ?80% T Cells And ?1% B Cells, With A Mixture Of Transgene Positive (>3.4%) And Negative T Cells. The Cd4+ And Cd8+ Naïve T Cell Subsets (Cd45Ra+Ccr7+) Present In The Leukapheresis Material Are Largely Retained

cd19-cd34t metabolically programmed car transduced t-cells

cd19-ucart

Clic-1901

Cytokine-Treated Veto Cells

Gdc-0199

Parsaclisib

Roginolisib

tqb3909

Vnx-101

Loncastuximab Tesirine

Prgn-3007

64Cu-LLP2A