231 assets in Endometrial Carcinoma

Rezatapopt

Sarilumab

Saruparib

SL-28

t3011

tcc1727

T-Dxd

Ter-2013

Tocilizumab

Toripalimab

Torvutatug Samrotecan

tt-10

tt-4

Tulmimetostat

Ubamatamab

XS-02

Atezolizumab

Fosifloxuridine Nafalbenamide

NC 410

prt3645

rp903

Adu-1805

ai-061

Alta2618

Amt-151

asp1893

Atv-1601

Atx-559

Autologous Cd3+ Enriched T Lymphocytes Obtained From Peripheral Blood Mononuclear Cells (Pbmcs) By Apheresis. The Cells Are Transduced With A Self-Inactivating, Non-Replicating Lentiviral Vector Encoding An Enhanced-Affinity T Cell Receptor (Tcr) Targeting The Hla-A*02:01-Restricted Mage-A4 Peptide (Gvydgrehtv) Alongside The Cd8 Alpha (Cd8?) Co-Receptor. The Expressed Transgene Comprises The Coding Sequence For The Cd8? Co-Receptor, Separated By A Foot-And-Mouth Disease Virus 2A Self-Cleaving Peptide Sequence From The Coding Sequence Of The Mage-A4 T-Cell Receptor Alpha And Beta Chains That Are Separated From Each Other By A Porcine Teschovirus-1 2A Self-Cleaving Peptide Sequence, Under Control Of The Human Elongation Factor 1 Alpha (Ef-1?) Promoter. The Construct Is Flanked By 5' And 3' Long Terminal Repeats (Ltrs) And Also Contains A Trna Primer Binding Site, A ? Packaging Signal, A Truncated Gag, A Rev Response Element (Rre) And A Central Polypurine Tract (Cppt) Sequence 5' To The Transgene, And A Polypurine Tract (Ppt) 3' To The Transgene. The Vector Is Pseudotyped With The Vesicular Stomatitis Virus (Vsv) G Envelope Glycoprotein. The Cd3+ T Lymphocytes Are Purified And Activated Using Anti-Cd3/Anti-Cd28 Monoclonal Antibody Coated Magnetic Beads. The Cells Are Then Cultured In Media Containing Interleukin 2 (Il-2), Human Ab Serum And A Protein Kinase B (Akt Inhibitor). The Cells Are Cd3+ (> 80%), Express The High Affinity Mage-A4 Specific Tcr And Cd8? Co-Receptor (Cd8? +Tcr+; >16%) And Are Cytotoxic To Mage-A4 Expressing Tumor Cells

AZD0240

azd0240: autologous, engineered t cells targeting kras g12d

Balstilimab

bg-68501

Bgb-43395

bl0175

Bl-M07D1

Botensilimab

bp1001-a

cgt6297

Cirtociclib

Ctim-76

Ctx-10726

Dat-2645

dr-0202

Drug Product De-Til-0255

hh160

Hwk-007

Hwk-016, Mucin-16-Targeted Adc

Ide-161

Imlunestrant