142 assets in Head And Neck Cancer

e-602

H-Gamma1 Heavy Chain Homo Sapiens (1-447) [Vh (Homo Sapiens Ighv4-59*01 (99.0%) -(Ighd) -Ighj3*02 (93.3%) T125>I (114), Cdr-Imgt [8.7.11] (26-33.51-57.96-106)) (1-117) -Homo Sapiens Ighg1*01, G1M17,1 Ch1 K120, Ch3 D12, L14, 9-G1V21 Ch2 Y15.1, T16, E18 (Ch1 K120 (214) (118-215), Hinge 1-15 (216-230), Ch2 M15.1>Y (252), S16>T (254), T18>E (256) (231-340), Ch3 D12 (356), L14 (358) (341-445), Chs (446-447)) (118-447)], (220-214')-Disulfide With L-Kappa Light Chain Homo Sapiens (1'-214') [V-Kappa (Homo Sapiens Igkv3-11*01 (96.8%) -Igkj4*01 (100%), Cdr-Imgt [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo Sapiens Igkc*01 (100%) Km3 A45.1, V101 (Ckappa A45.1 (153'), V101 (191')) (108'-214')]; Dimer (226-226'':229-229'')-Bisdisulfide, Produced In A Cell Line Derived From Chinese Hamster Ovary (Cho) Cells, Glycoform Alfa

Immunotherapic Bifunctional Fusion Protein Comprised Of A Fully Human Igg1 Monoclonal Antibody (Avelumab) Against Human Programmed Death-Ligand 1 (Pd-L1) Fused To The Soluble Extracellular Domain Of Transforming Growth Factor-.Beta. (Tgf-.Beta.) Receptor Ii, Which Acts As A Tgf-.Beta. Trap

Nogapendekin Alfa Inbakicept

[203pb]pb-psv359

[212pb]pb-psv359

[212pb]vmt-alpha-net

Adoptive Therapy With Autologous Mc2 Tcr T Cells

Amxt1501

Autologous Rapamycin-Resistant Th1/Tc1 Cells Rapa-201

Clostridium Novyi-Nt

Crte7A2-01 Tcr-T Cell

Crte7A2-01 Tcr-T Cell Therapy

Eflornithine

gm103

Ide-161

Idov-Immune

ilb2109

Immunoglobulin G1-Kappa, Anti-[Homo Sapiens Met (Met Proto-Oncogene, Hepatocyte Growth Factor (Hgf) Receptor, Hgfr, Scatter Factor (Sf) Receptor, Hgf/Sf Receptor, Receptor Tyrosine-Protein Kinase C-Met, Papillary Renal Cell Carcinoma 2, Rccp2)] And Anti-[Homo Sapiens Egfr (Epidermal Growth Factor Receptor, Receptor Tyrosine-Protein Kinase Erbb-1, Erbb1, Her1, Her-1, Erbb)], Homo Sapiens Monoclonal Antibody, Bispecific

Inbrx-106

Inupadenant

Ixovex-1

mdx2001

Oxodotreotide

Pedmark® Sts

Recombinant Fully Human Igg1 Kappa Anti-Tigit Monoclonal Antibody Eos-448

Rezatapopt

scg142 tcr-t cells

Solnerstotug

S<Sup>3.15</Sup>,S<Sup>3.22</Sup>,S<Sup>3.29</Sup>-[(1,3,5-Triazinane-1,3,5-Triyl)Tris(3-Oxopropane-3,1-Diyl)]{N-[5-Oxo-5-({L-Valyl-N<Sup>5</Sup>-Carbamoyl-L-Ornithyl[(4-Aminophenyl)Methoxy]Carbonyl-N-Methyl-L-Valyl-Lvalyl-(3R,4S,5S)-3-Methoxy-5-Methyl-4-(Methylamino)Heptanoyl-(2R,3R)-N-[(1S,2R)-1-Hydroxy-1-Phenylpropan-2-Yl]-3-Methoxy-2-Methyl-3-[(2S)-Pyrrolidin-2-Yl]Propanamide}-N2.1-Yl)Pentanoyl]-?-Alanyldecakis(N-Methylglycyl)-L-Alanyl-N6-Carbamimidoyl-L-Lysyl-L-?-Aspartyl-L-Cysteinyl-(4R)-4-Hydroxy-L-Prolyl-L-Leucyl-L-Valyl-L-Asparaginyl-L-Prolyl-L-Leucyl-L-Cysteinyl-L-Leucyl-L-Histidyl-L-Prolyl-D-?-Aspartyl-L-Tryptophyl-N6-Carbamimidoyl-L-Lysyl-Lcysteinamide}

SX682

Tiragolumab

Toripalimab

Valemetostat

Veliparib

bi 765049

Cdx-585

Ezabenlimab

PRT1419

Tigilanol Tiglate

[177lu]lu-akir001

[177Lu]Lu-HT547

[225Ac]Ac-AKY-1189

[64Cu]Cu-AKY-1189

[⁶⁸Ga]Ga-HT547

alx2004

Amivantamab-Vmjw

Autologous Cd3+ Enriched T Lymphocytes Obtained From Peripheral Blood Mononuclear Cells (Pbmcs) By Apheresis. The Cells Are Transduced With A Self-Inactivating, Non-Replicating Lentiviral Vector Encoding An Enhanced-Affinity T Cell Receptor (Tcr) Targeting The Hla-A*02:01-Restricted Mage-A4 Peptide (Gvydgrehtv) Alongside The Cd8 Alpha (Cd8?) Co-Receptor. The Expressed Transgene Comprises The Coding Sequence For The Cd8? Co-Receptor, Separated By A Foot-And-Mouth Disease Virus 2A Self-Cleaving Peptide Sequence From The Coding Sequence Of The Mage-A4 T-Cell Receptor Alpha And Beta Chains That Are Separated From Each Other By A Porcine Teschovirus-1 2A Self-Cleaving Peptide Sequence, Under Control Of The Human Elongation Factor 1 Alpha (Ef-1?) Promoter. The Construct Is Flanked By 5' And 3' Long Terminal Repeats (Ltrs) And Also Contains A Trna Primer Binding Site, A ? Packaging Signal, A Truncated Gag, A Rev Response Element (Rre) And A Central Polypurine Tract (Cppt) Sequence 5' To The Transgene, And A Polypurine Tract (Ppt) 3' To The Transgene. The Vector Is Pseudotyped With The Vesicular Stomatitis Virus (Vsv) G Envelope Glycoprotein. The Cd3+ T Lymphocytes Are Purified And Activated Using Anti-Cd3/Anti-Cd28 Monoclonal Antibody Coated Magnetic Beads. The Cells Are Then Cultured In Media Containing Interleukin 2 (Il-2), Human Ab Serum And A Protein Kinase B (Akt Inhibitor). The Cells Are Cd3+ (> 80%), Express The High Affinity Mage-A4 Specific Tcr And Cd8? Co-Receptor (Cd8? +Tcr+; >16%) And Are Cytotoxic To Mage-A4 Expressing Tumor Cells

Autologous Genetically Modified Mage-A4ᶜ¹º³²T Cells

Bdc-3042