(6S)-L-ERYTHRO-TETRAHYDROBIOPTERIN
Hyperphenylalaninemia Due To Tetrahydrobiopterin Deficiency
Floatz Rating
CC43/100
Confidence
Indicative
Sponsor
University of Massachusetts, Amherst
Modality
Small molecule
Development Phase
Phase 1
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04014712CT.gov O2 Transport and Utilization in Health and Lung Disease | — | Withdrawn | — | — | — |
NCT01541397CT.gov Bone Mineral Density in Adults With Hyperphenylalaninemia on Kuvan Therapy | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Hyperphenylalaninemia Due To Tetrahydrobiopterin Deficiency
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| (6S)-L-ERYTHRO-TETRAHYDROBIOPTERIN (this asset) | University of Massachusetts, Amherst | P1 | CC · 43 |
| Sepiapterin | PTC Therapeutics | P1/2 | CCC |
| Phenoptin | BioMarin Pharmaceutical | P2 | NR |
| Sapropterin Dihydrochloride | BioMarin Pharmaceutical | Unk | NR |
Other indications for (6S)-L-ERYTHRO-TETRAHYDROBIOPTERIN
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Lesch-Nyhan Syndrome | — | P2/3 | B · 56 |
| Portal Hypertension | — | P2/3 | B · 56 |
| Phenylketonuria | — | P2 | CCC · 53 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. (6S)-L-ERYTHRO-TETRAHYDROBIOPTERIN in Hyperphenylalaninemia Due To Tetrahydrobiopterin Deficiency. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/6s-l-erythro-tetrahydrobiopterin-hyperphenylalaninemia-due-to-tetrahydrobiopterin-deficiency
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