Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
Aadi Bioscience, Inc.
Modality
UNKNOWN
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03747328CT.gov ABI-009 (Nab-sirolimus) in Patients With Genetically-confirmed Leigh or Leigh-like Syndrome | — | Withdrawn | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89Moderate confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Leigh Syndrome
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Abi-009 (this asset) | Aadi Bioscience, Inc. | P2 | CCC · 53 |
| Alpha-Tocotrienol Quinone | PTC Therapeutics | P2 | B |
| Sonlicromanol | Khondrion BV | P2 | B |
| Sirolimus | Matthew Demczko | P2 | CCC |
| Mannitol | Thiogenesis Therapeutics, Inc. | P2 | CCC |
| Tti-0102: Cysteamine-Pantetheine Disulfide | Thiogenesis Therapeutics, Inc. | P2 | NR |
| Vatiquinone | PTC Therapeutics | P2/3 | NR |
Other indications for Abi-009
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Neoplasm | — | P1 | CC · 40 |
| Plasma Cell Myeloma | — | P1 | C · 36 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Abi-009 in Leigh Syndrome. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/abi-009-leigh-syndrome
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