Floatz Rating
B60/100
Confidence
Indicative
Sponsor
Khondrion BV
Modality
Small molecule
Development Phase
Phase 2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
45High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04846036CT.gov The KHENERGYC Study | — | Suspended | — | — | — |
NCT02544217CT.gov A Dose-escalating Clinical Trial With KH176 | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Leigh Syndrome
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Sonlicromanol (this asset) | Khondrion BV | P2 | B · 60 |
| Alpha-Tocotrienol Quinone | PTC Therapeutics | P2 | B |
| Sirolimus | Matthew Demczko | P2 | CCC |
| Abi-009 | Aadi Bioscience, Inc. | P2 | CCC |
| Mannitol | Thiogenesis Therapeutics, Inc. | P2 | CCC |
| Tti-0102: Cysteamine-Pantetheine Disulfide | Thiogenesis Therapeutics, Inc. | P2 | NR |
| Vatiquinone | PTC Therapeutics | P2/3 | NR |
Other indications for Sonlicromanol
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| MELAS Syndrome | — | P3 | BB · 70 |
| Mitochondrial Disease | — | P3 | BB · 70 |
| Maternally-Inherited Diabetes And Deafness | — | P3 | BB · 66 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Sonlicromanol in Leigh Syndrome. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/sonlicromanol-leigh-syndrome
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