Floatz Rating
CCC54/100
Confidence
Indicative
Sponsor
Columbia University
Modality
Small molecule
Development Phase
Phase 4 / Approved
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
39Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT01129557CT.gov Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney Disease | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · IgA Glomerulonephritis
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Aliskiren (this asset) | Columbia University | Approved | CCC · 54 |
| Valsartan | Columbia University | P4 | BB |
| Prednisone | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | P2 | B |
| Bardoxolone Methyl Ester | Biogen | P2 | B |
| Ucar T-Cell | The Children's Hospital of Zhejiang University School of Medicine | P1 | CCC |
| qt-219cx | The Children's Hospital of Zhejiang University School of Medicine | Early P1 | C |
| RD06-05 CART Cell | The Children's Hospital of Zhejiang University School of Medicine | Early P1 | C |
| Enalapril | National Center for Research Resources (NCRR) | N/A | D |
Other indications for Aliskiren
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Hypertensive Disorder | — | P4 | BB · 68 |
| Abdominal Obesity-Metabolic Syndrome | — | P4 | B · 59 |
| Proteinuria | — | P4 | CCC · 54 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Aliskiren in IgA Glomerulonephritis. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/aliskiren-iga-glomerulonephritis
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