Anti-Mesothelin Chimeric T Cell Receptor Transduced Peripheral Blood Lymphocytes
Mesothelioma
Explore 56 assets in Mesothelioma →Floatz Rating
CC43/100
Confidence
Indicative
Sponsor
National Cancer Institute (NCI)
Modality
Cell therapy
Development Phase
Phase 1/2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
33Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT01583686CT.gov CAR T Cell Receptor Immunotherapy Targeting Mesothelin for Patients With Metastatic Cancer | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Mesothelioma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Anti-Mesothelin Chimeric T Cell Receptor Transduced Peripheral Blood Lymphocytes (this asset) | National Cancer Institute (NCI) | P1/2 | CC · 43 |
| Cyclophosphamide | National Cancer Institute (NCI) | P2 | B |
| Fludarabine | National Cancer Institute (NCI) | P2 | B |
| Nivolumab | Orion Corporation, Orion Pharma | P2 | B |
| 18f-fspg | Andrei Iagaru | P2 | CCC |
| Irinotecan | Genmab | P1/2 | CCC |
| Pembrolizumab | Genmab | P2 | CCC |
| Tazemetostat | Epizyme, Inc. | P1/2 | CCC |
| Immunoglobulin G1, Anti-(Mesothelin) (Human-Mouse Monoclonal Morab-009 Heavy Chain), Disulfide With Human-Mouse Monoclonal Morab-009 .Kappa.-Chain, Dimer | Morphotek | P1 | CCC |
+42 more in the Mesothelioma cohort
Other indications for Anti-Mesothelin Chimeric T Cell Receptor Transduced Peripheral Blood Lymphocytes
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Cervical Cancer | — | P1/2 | CC · 41 |
| Lung Cancer | — | P1/2 | CC · 41 |
| Pancreatic Neoplasm | — | P1/2 | CC · 40 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Anti-Mesothelin Chimeric T Cell Receptor Transduced Peripheral Blood Lymphocytes in Mesothelioma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 14, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/anti-mesothelin-chimeric-t-cell-receptor-transduced-peripheral-blood-lymphocytes-mesothelioma
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