Autologous Cd4+ And Cd8+ T Cells, Enriched From Peripheral Blood Mononuclear Cells (Pbmcs) Obtained By Apheresis Transduced Ex Vivo With A Non-Replicating, Self-Inactivating (Sin) Lentiviral Vector, Encoding A Chimeric Antigen Receptor (Car) Consisting Of An Anti-Cd19 Specific Scfv, A Cd8.Alpha. Stalk, Transmembrane Domain And Anchor, A 41Bb Endodomain And A Cd3 Zeta Endodomain, Under The Control Of A Human Pgk1 Promoter And A Modified Woodchuck Post Transcriptional Response Element. The Vector Genome Also Contains A 5' Terminal Cmv Enhancer/Promoter, A .Psi. Packaging Signal, A Rev Response Element (Rre) And A Central Polypurine Tract (Cppt)
Adult Acute Lymphoblastic Leukemia
Explore 66 assets in Adult Acute Lymphoblastic Leukemia →Floatz Rating
D30/100
Confidence
Indicative
Sponsor
Modality
Cell therapy
Development Phase
Unknown
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
15Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06799221CT.gov Expanded Access Program for OOS Obe-cel | — | Available | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Adult Acute Lymphoblastic Leukemia
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Autologous Cd4+ And Cd8+ T Cells, Enriched From Peripheral Blood Mononuclear Cells (Pbmcs) Obtained By Apheresis Transduced Ex Vivo With A Non-Replicating, Self-Inactivating (Sin) Lentiviral Vector, Encoding A Chimeric Antigen Receptor (Car) Consisting Of An Anti-Cd19 Specific Scfv, A Cd8.Alpha. Stalk, Transmembrane Domain And Anchor, A 41Bb Endodomain And A Cd3 Zeta Endodomain, Under The Control Of A Human Pgk1 Promoter And A Modified Woodchuck Post Transcriptional Response Element. The Vector Genome Also Contains A 5' Terminal Cmv Enhancer/Promoter, A .Psi. Packaging Signal, A Rev Response Element (Rre) And A Central Polypurine Tract (Cppt) (this asset) | Unk | D · 30 | |
| Mercaptopurine Anhydrous | Shanxi Bethune Hospital | P4 | A |
| Dexasone | Shanxi Bethune Hospital | P4 | BBB |
| Cytarabine | PETHEMA Foundation | P4 | BBB |
| Cyclophosphamide | The First Affiliated Hospital of Zhengzhou University | P4 | BBB |
| Asparaginase | Institute of Hematology & Blood Diseases Hospital, China | P4 | BBB |
| Vindesine | Shanxi Bethune Hospital | P4 | BBB |
| Adriamycin | University of Washington | P4 | BBB |
| Methotrexate | PETHEMA Foundation | P4 | BBB |
+42 more in the Adult Acute Lymphoblastic Leukemia cohort
Other indications for Autologous Cd4+ And Cd8+ T Cells, Enriched From Peripheral Blood Mononuclear Cells (Pbmcs) Obtained By Apheresis Transduced Ex Vivo With A Non-Replicating, Self-Inactivating (Sin) Lentiviral Vector, Encoding A Chimeric Antigen Receptor (Car) Consisting Of An Anti-Cd19 Specific Scfv, A Cd8.Alpha. Stalk, Transmembrane Domain And Anchor, A 41Bb Endodomain And A Cd3 Zeta Endodomain, Under The Control Of A Human Pgk1 Promoter And A Modified Woodchuck Post Transcriptional Response Element. The Vector Genome Also Contains A 5' Terminal Cmv Enhancer/Promoter, A .Psi. Packaging Signal, A Rev Response Element (Rre) And A Central Polypurine Tract (Cppt)
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| B-Cell Acute Lymphoblastic Leukemia | — | P1/2 | CCC · 54 |
| B-Cell Non-Hodgkin Lymphoma | — | P1 | CC · 43 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Autologous Cd4+ And Cd8+ T Cells, Enriched From Peripheral Blood Mononuclear Cells (Pbmcs) Obtained By Apheresis Transduced Ex Vivo With A Non-Replicating, Self-Inactivating (Sin) Lentiviral Vector, Encoding A Chimeric Antigen Receptor (Car) Consisting Of An Anti-Cd19 Specific Scfv, A Cd8.Alpha. Stalk, Transmembrane Domain And Anchor, A 41Bb Endodomain And A Cd3 Zeta Endodomain, Under The Control Of A Human Pgk1 Promoter And A Modified Woodchuck Post Transcriptional Response Element. The Vector Genome Also Contains A 5' Terminal Cmv Enhancer/Promoter, A .Psi. Packaging Signal, A Rev Response Element (Rre) And A Central Polypurine Tract (Cppt) in Adult Acute Lymphoblastic Leukemia. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/autologous-cd4-and-cd8-t-cells-enriched-from-peripheral-blood-mononuclear-cells-pbmcs-obtained-by-apheresis-transduced-ex-vivo-with-a-non-replicating-self-inactivating-sin-lentiviral-vector-encoding-a-chimeric-antigen-receptor-car-consisting-of-an-anti-cd19-specific-scfv-a-cd8alpha-stalk-transmembrane-domain-and-anchor-a-41bb-endodomain-and-a-cd3-zeta-endodomain-under-the-control-of-a-human-pgk1-promoter-and-a-modified-woodchuck-post-transcriptional-response-element-the-vector-genome-also-contains-a-5-terminal-cmv-enhancerpromoter-a-psi-packaging-signal-a-rev-response-element-rre-and-a-central-polypurine-tract-cppt-adult-acute-lymphoblastic-leukemia
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