Autologous Cd4+ And Cd8+ T Cells, Enriched From Peripheral Blood Mononuclear Cells (Pbmcs) Obtained By Apheresis Transduced Ex Vivo With A Non-Replicating, Self-Inactivating (Sin) Lentiviral Vector, Encoding A Chimeric Antigen Receptor (Car) Consisting Of An Anti-Cd19 Specific Scfv, A Cd8.Alpha. Stalk, Transmembrane Domain And Anchor, A 41Bb Endodomain And A Cd3 Zeta Endodomain, Under The Control Of A Human Pgk1 Promoter And A Modified Woodchuck Post Transcriptional Response Element. The Vector Genome Also Contains A 5' Terminal Cmv Enhancer/Promoter, A .Psi. Packaging Signal, A Rev Response Element (Rre) And A Central Polypurine Tract (Cppt)

Creator: Floatz
License: https://terminal.floatz.ai/terms

B-Cell Non-Hodgkin Lymphoma

Explore 306 assets in B-Cell Non-Hodgkin Lymphoma →

Floatz Rating

CC43/100

Confidence

Indicative

v0.2

Sponsor

Autolus Limited

Modality

Cell therapy

Development Phase

Phase 1

Status

Active

Evidence ledger · v0.2

Clinical Evidence

28Moderate confidence

Detailed axis rationale is planned and will be published soon.

Trial	Phase	Status	N	Primary endpoint	Readout
NCT06173518CT.gov A Study of CD19 Targeted CAR T Cell Therapy in Pediatric Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia (B ALL) and Aggressive Mature B-cell Non-Hodgkin Lymphoma (B NHL)	—	Recruiting	—	—	—

Competitive Position

95High confidence

Detailed axis rationale is planned and will be published soon.

Same indication · B-Cell Non-Hodgkin Lymphoma

Asset	Sponsor	Phase	Rating
Autologous Cd4+ And Cd8+ T Cells, Enriched From Peripheral Blood Mononuclear Cells (Pbmcs) Obtained By Apheresis Transduced Ex Vivo With A Non-Replicating, Self-Inactivating (Sin) Lentiviral Vector, Encoding A Chimeric Antigen Receptor (Car) Consisting Of An Anti-Cd19 Specific Scfv, A Cd8.Alpha. Stalk, Transmembrane Domain And Anchor, A 41Bb Endodomain And A Cd3 Zeta Endodomain, Under The Control Of A Human Pgk1 Promoter And A Modified Woodchuck Post Transcriptional Response Element. The Vector Genome Also Contains A 5' Terminal Cmv Enhancer/Promoter, A .Psi. Packaging Signal, A Rev Response Element (Rre) And A Central Polypurine Tract (Cppt) (this asset)	Autolus Limited	P1	CC · 43
Vindesine	Children's Cancer Group, China	P4	BBB
Anti-Cd20/Cd3 Monoclonal Antibody Regn1979	University of Birmingham	P3	BBB
Cytarabine	Children's Cancer Group, China	P4	BBB
Camustine	Federal Research Institute of Pediatric Hematology, Oncology and Immunology	P4	BBB
Zanubrutinib	The First Affiliated Hospital of Soochow University	P4	BBB
Isocyclophosphamide	Shanghai Junshi Bioscience Co., Ltd.	P4	BBB
Autologous Cd4+ And Cd8+ T Cells, Enriched From Peripheral Blood Mononuclear Cells (Pbmcs) Transduced With A Nonreplicative Self-Inactivating (Sin) Lentiviral Vector Encoding A Chimeric Antigen Receptor (Car) Consisting Of The Human Cd19-Specific Scfv, An Lgg4 Hinge Region, Cd28 Transmembrane Domain, Cd137 (4-1Bb) Co-Stimulatory Domain And Cd3 Zeta Signalling Domain, Under The Control Of A Hybrid Elongation Factor 1 Alpha (Ef1.Alpha.) And Human T Cell Leukemia Virus Type 1(Htlv-1) Regulatory Element Promoter And Woodchuck Hepatitis Virus Post-Transcriptional Regulatory Element (Wpre). The Vector Genome Also Encodes A Truncated Human Epidermal Growth Factor Receptor (Egfrt) That Is Co-Expressed With The Car And Cleaved From It By The T2A Self-Cleaving Peptide. The Vector Genome Also Contains A Splice Donor, A Fragment Of Gag, A Rev Response Element (Rre), A Mutated Central Polypurine Tract (Cppt), And A Splice Acceptor	Ruijin Hospital	P4	BBB
Tacrolimus	M.D. Anderson Cancer Center	P2	BB

+42 more in the B-Cell Non-Hodgkin Lymphoma cohort

Other indications for Autologous Cd4+ And Cd8+ T Cells, Enriched From Peripheral Blood Mononuclear Cells (Pbmcs) Obtained By Apheresis Transduced Ex Vivo With A Non-Replicating, Self-Inactivating (Sin) Lentiviral Vector, Encoding A Chimeric Antigen Receptor (Car) Consisting Of An Anti-Cd19 Specific Scfv, A Cd8.Alpha. Stalk, Transmembrane Domain And Anchor, A 41Bb Endodomain And A Cd3 Zeta Endodomain, Under The Control Of A Human Pgk1 Promoter And A Modified Woodchuck Post Transcriptional Response Element. The Vector Genome Also Contains A 5' Terminal Cmv Enhancer/Promoter, A .Psi. Packaging Signal, A Rev Response Element (Rre) And A Central Polypurine Tract (Cppt)

Indication	Sponsor	Phase	Rating
B-Cell Acute Lymphoblastic Leukemia	—	P1/2	CCC · 54
Adult Acute Lymphoblastic Leukemia	—	Unk	D · 30

Scientific Foundation

Planned for methodology v0.2.

Development Feasibility

Planned for methodology v0.2.

Commercial Opportunity

Planned for methodology v0.2.

IP & Exclusivity

Planned for methodology v0.2.

Manufacturing & Supply

Planned for methodology v0.2.

Related assets

Citation

Floatz Terminal. Autologous Cd4+ And Cd8+ T Cells, Enriched From Peripheral Blood Mononuclear Cells (Pbmcs) Obtained By Apheresis Transduced Ex Vivo With A Non-Replicating, Self-Inactivating (Sin) Lentiviral Vector, Encoding A Chimeric Antigen Receptor (Car) Consisting Of An Anti-Cd19 Specific Scfv, A Cd8.Alpha. Stalk, Transmembrane Domain And Anchor, A 41Bb Endodomain And A Cd3 Zeta Endodomain, Under The Control Of A Human Pgk1 Promoter And A Modified Woodchuck Post Transcriptional Response Element. The Vector Genome Also Contains A 5' Terminal Cmv Enhancer/Promoter, A .Psi. Packaging Signal, A Rev Response Element (Rre) And A Central Polypurine Tract (Cppt) in B-Cell Non-Hodgkin Lymphoma. Methodology v0.2.
Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026.
Accessed July 14, 2026.
https://terminal.floatz.ai/assets/autologous-cd4-and-cd8-t-cells-enriched-from-peripheral-blood-mononuclear-cells-pbmcs-obtained-by-apheresis-transduced-ex-vivo-with-a-non-replicating-self-inactivating-sin-lentiviral-vector-encoding-a-chimeric-antigen-receptor-car-consisting-of-an-anti-cd19-specific-scfv-a-cd8alpha-stalk-transmembrane-domain-and-anchor-a-41bb-endodomain-and-a-cd3-zeta-endodomain-under-the-control-of-a-human-pgk1-promoter-and-a-modified-woodchuck-post-transcriptional-response-element-the-vector-genome-also-contains-a-5-terminal-cmv-enhancerpromoter-a-psi-packaging-signal-a-rev-response-element-rre-and-a-central-polypurine-tract-cppt-b-cell-non-hodgkin-lymphoma

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