Dordaviprone
Endometrial Serous Adenocarcinoma
Explore 12 assets in Endometrial Serous Adenocarcinoma →Floatz Rating
C39/100
Confidence
Indicative
Sponsor
UNC Lineberger Comprehensive Cancer Center
Modality
Small molecule
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
24Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05542407CT.gov ONC201 and Atezolizumab in Obesity-Driven Endometrial Cancer | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Endometrial Serous Adenocarcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Dordaviprone (this asset) | UNC Lineberger Comprehensive Cancer Center | P1 | C · 39 |
| Carboplatin | National Cancer Institute (NCI) | P3 | BB |
| Temsirolimus | National Cancer Institute (NCI) | P2 | B |
| Cediranib | National Cancer Institute (NCI) | P2 | B |
| Cabozantinib | National Cancer Institute (NCI) | P2 | B |
| Pembrolizumab | Roswell Park Cancer Institute | P2 | CCC |
| Doxycycline | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | P2 | CCC |
| Olaparib | National Cancer Institute (NCI) | P2 | CCC |
| Capivasertib | National Cancer Institute (NCI) | P2 | CCC |
+14 more in the Endometrial Serous Adenocarcinoma cohort
Other indications for Dordaviprone
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Glioblastoma | — | P2 | CCC · 48 |
| Triple-Negative Breast Carcinoma | — | P2 | CC · 47 |
| Endometrial Carcinoma | — | P2 | CC · 47 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Dordaviprone in Endometrial Serous Adenocarcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/dordaviprone-endometrial-serous-adenocarcinoma
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