Entospletinib
Acute Myeloid Leukemia With Mutated NPM1
Explore 14 assets in Acute Myeloid Leukemia With Mutated NPM1 →Floatz Rating
CC40/100
Confidence
Indicative
Sponsor
Kronos Bio
Modality
Small molecule
Development Phase
Phase 3
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
25Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05020665CT.gov Entospletinib Plus Intensive Induction/Consolidation Chemotherapy in Newly Diagnosed NPM1-mutated AML | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Acute Myeloid Leukemia With Mutated NPM1
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Entospletinib (this asset) | Kronos Bio | P3 | CC · 40 |
| Cytarabine | Shen yang | P3 | B |
| Azacitidine | Shen yang | P2 | B |
| Venetoclax | Kura Oncology, Inc. | P2 | B |
| Daunomycin | Shen yang | P2 | B |
| Arsenic Trioxide | The University of Hong Kong | P2 | CCC |
| BN104 | Institut de Recherches Internationales Servier (I.R.I.S.) | P1/2 | CC |
| Mezigdomide | Massachusetts General Hospital | P1 | CC |
| Revumenib | National Cancer Institute (NCI) | P1 | CC |
+6 more in the Acute Myeloid Leukemia With Mutated NPM1 cohort
Other indications for Entospletinib
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma | — | P2 | CC · 45 |
| Mantle Cell Lymphoma | — | P2 | CC · 42 |
| Follicular Lymphoma | — | P2 | CC · 42 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Entospletinib in Acute Myeloid Leukemia With Mutated NPM1. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/entospletinib-acute-myeloid-leukemia-with-mutated-npm1
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